With the help of a simple 20-letter lattice model of heteropolymers, we investigated the energy landscape in the space of designed good-folder sequences. Low-energy sequences form clusters, interconnected via neutral networks, in the space of sequences. Residues that play a key role in the foldability of the chain and in the stability of the native state are highly conserved, even among the cha...

Cover Figure: Purple bacteria live at the bottom of ponds or lakes, and some purple bacteria can harvest light and produce energy through photosynthesis. Their photosynthetic apparatus are found inside the bacterial membrane, consisting of several proteins. One of these proteins is the ring-like Light Harvesting Complex 2, the protein investigated in this case study. All files can be found in t...

Fractal structures are found in biomedical time series from a wide range of physiological phenomena. The multifractal spectrum identifies the deviations in fractal structure within time periods with large and small fluctuations. The present tutorial is an introduction to multifractal detrended fluctuation analysis (MFDFA) that estimates the multifractal spectrum of biomedical time series. The t...

During the past year the activities of the Chemical Thermodynamics Data Center and the JANAF Thermochemical Tables project have been combined to obtain an extensive collection of thermodynamic information for many chemical species, including the elements. Currently available are extensive bibliographic collections and data files of heat capacity, enthalpy, vapor pressure, phase transitions, etc...

Protein-engineering methods (Phi-values) were used to investigate the folding transition state of a lysin motif (LysM) domain from Escherichia coli membrane-bound lytic murein transglycosylase D. This domain consists of just 48 structured residues in a symmetrical betaalphaalphabeta arrangement and is the smallest alphabeta protein yet investigated using these methods. An extensive mutational a...

In the clinical practice, it is much more efficient to use NiTi rotary files compared to hand instrumentation. However, misuse of NiTi rotary files can result in procedural errors such as transportation, ledge, perforation, and file separation. Generally, following suggestions could be considered to avoid these errors. 1. Enlarge the coronal half of the root canal before preparing the apical pa...

The SL~IQX 'invisible' fonts are currently produced by a special set of METAFONT files; an alternative method of generating 'invisible' versions of any font is presented, using virtual fonts.

This is a cross sectional study in 5 GP Training Practices, sample size 100 clinically stable patients, attending for routine care. Purpose of the study was explained and informed written consent was sought. Participants were provided with 'Think Ahead,' an innovative end of life planning tool, devised by The Forum on The End of Life, based on best international practice, presented in a questio...