Purpose: The aim of this study was to enhance the dissolution rate of Cyclosporine A, a poorly water-soluble drug by developing a self micro-emulsifying (SME) tablet formulation by using the liquisolid compact technique. A liquisolid system is formed by converting a liquid formulation into a dry, free-flowing and compressible powder mixture with selected carrier material and coating material. T...

Abstract To improve the resource utilization of solid waste, excavation abandoned soil and red mud, a by-product alumina industry, were introduced into preparation controlled low strength material (CLSM). By carrying out flowability test, bleeding test compressive relationship between properties CLSM mixture amount mud was analysed. The experiment results indicate that rate decrease with increa...

This study experimentally and theoretically examined the flowability cohesiveness for powder using a test of discharge through an orifice by pressurized air. The used consisted two kinds Calcium hydroxide which have different particle sizes granulation. These are 11µm 176µm, those called Ca(OH) 2 -A -B. Cohesiveness is characterized Bond number ratio separation force to gravity force. Flowabili...

Objective(s):The aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. Quasi-emulsion solvent diffusion was used as a crystal modification method. Materials and Methods: Corn starch was dissolved in hydrochloric acid at 80˚C and then ethanol as a non-solvent was added with lowering temperature ...

Atmospheric humidity is introduced into powders during handling, transportation, and storage. High moisture content can increase cohesive forces between particles make it difficult to spread a powder thin layers in bed processes or fill mold such as press-and-sinter. Furthermore, water cause porosity uptake of oxygen the final component, damaging its mechanical properties. In this study, Freema...

Furosemid (FUR) adalah obat diuretik kuat yang umum dipakai untuk pengobatan tekanan darah tinggi dan lemah jantung. Bahan baku FUR memiliki kemampuan mengalir (flowability) dikempa menjadi tablet (tabletability) buruk. Pada penelitian memperbaiki flowability tabletability furosemid diperbaiki melalui pembentukkan ko-kristal dengan kafein (CAF). Metode Ultrasound Assisted Solution Co-Crystaliza...