Probe has been developed as the first ratiometric fluorescent cobalt probe with high sensitivity and selectivity based on internal charge transfer (ICT). Most importantly, the probe achieved the imaging and detection of cobalt in cells with ratiometric measurement.

Multilayered, core/shell nanoprobes (MQQ-probe) based on magnetic nanoparticles (MNPs) and quantum dots (QDs) have been successfully developed for multimodality tumor imaging. This MQQ-probe contains Fe(3)O(4) MNPs, visible-fluorescent QDs (600 nm emission) and near infrared-fluorescent QDs (780 nm emission) in multiple silica layers. The fabrication of the MQQ-probe involves the synthesis of a...

Collagen is the protein primarily responsible for the load-bearing properties of tissues and collagen architecture is one of the main determinants of the mechanical properties of tissues. Visualisation of changes in collagen three-dimensional structure is essential in order to improve our understanding of collagen fibril formation and remodelling, e.g. in tissue engineering experiments. A recen...

A reductive ligation based fluorescent probe () for the detection of S-nitrosothiols (SNO) was developed. The probe showed good selectivity and sensitivity for SNO.

objective: synthetic fluorescent dyes that are conjugated to antibodies are useful tools to probe molecules. based on dye chemical structures, their photobleaching and photostability indices are quite diverse. it is generally believed that among different fluorescent dyes, alexa fluor family has greater photostability than traditional dyes like fluorescein isothiocyanate (fitc) and cy5. alexa f...

A new type of ratiometric fluorescent probe, 8-(diethylamino)-2-methyl-4-oxo-4H-pyrano[2,3-b] chromen-10-ylium tetrafluoroborate (APCT), is reported. A new type of ratiometric fluorescent probe, 8(diethylamino)-2-methyl-4-oxo-4H-pyrano[2,3-b]chromen-10-ylium tetrafluoroborate (APCT), is reported. This probe can successfully detect bisulfite anions with a detection limit of 6.1 10 7 M based on M...

Pyrrolo-C (PC), or 3-[beta-D-2-ribofuranosyl]-6-methylpyrrolo[2,3-d]pyrimidin-2(3H)-one, is a fluorescent analog of the nucleoside cytidine that retains its Watson-Crick base-pairing capacity with G. Due to its red-shifted absorbance, it can be selectively excited in the presence of natural nucleosides, making it a potential site-specific probe for RNA structure and dynamics. Similar to 2-amino...

Acetylcholinesterase (AChE) enzyme which catalyses the hydrolysis of choline esters, such as acetylcholine, is very important in nerve function. Previous structural studies showed the possible amyloid fibril formation on the AChE. Therefore it is important to understand interaction of ligands to prevent the formation of  amyloid fibrils. The purpose of the present study was to  char...

The cover feature shows the detection and visualization of G-quadruplex (GQ) structures specific to mitochondrial DNA (mtDNA) using flavylium-methine fluorescent probe. selective localization binding probe mtDNA-GQ leads turn-on near infrared fluorescence response. cellular distribution organelle-specific accumulation within mitochondria. displayed independent membrane potential reiterating its...