BACKGROUND Patients with type 2 diabetes mellitus are at increased risk for the development of atherosclerosis. A pivotal event in the development of atherosclerosis is macrophage foam cell formation. The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 regulate macrophage cholesterol efflux and hence play a vital role in macrophage foam cell formation. We have previously found that chro...

1. Abstract 2. Introduction 3. Nature of lipid in foam cells 4. Sources of cholesterol that accumulates in foam cells 5. Significance of foam cell formation 5.1. Trapping lipid in lesions versus removing lipid from lesions 5.2. Alteration of macrophage function 6. The use of cultured macrophages to study foam cell formation 7. In vitro foam cell formation 7.1. Plasma lipoproteins 7.2. Non-lipop...

Current events across the globe necessitate rapid technological advances to combat the epidemic of nerve agent chemical weapons. Biocatalysis has emerged as a viable tool in the detoxification of organophosphorus neurotoxins, such as the chemical weapons VX and sarin. Efficient detoxification of contaminated equipment, machinery, and soils are of principal concern. This study describes the inco...

RATIONALE LKB1 (liver kinase B1) is a serine/threonine kinase and tumor suppressor, which regulates the homeostasis of hematopoietic cells and immune responses. Macrophages transform into foam cells upon taking-in lipids. No role for LKB1 in foam cell formation has previously been reported. OBJECTIVE We sought to establish the role of LKB1 in atherosclerotic foam cell formation. METHODS AND...

OBJECTIVE The majority of early trauma deaths are attributable to uncontrolled hemorrhage from truncal sites. A hemorrhage-control technique that reduced bleeding in the prehospital phase of treatment without requiring manual compression may improve the outcome of these patients. We conducted this preliminary study to determine whether an expanding fibrin sealant foam (FSF) would reduce bleedin...

The aim of this study was to evaluate the efficiency of polyurethane foam containing silver nanoparticles synthesized by Verbena officinalis leaf extract in controlling of Yersinia ruckeri in treatment of water tanks of rainbow trout farming. Biosynthesis of silver nanoparticles is done with 2mM silver nitrate solution and Verbena officinalis extract. To study antibacterial effects of the produ...

BACKGROUND The majority of early trauma deaths are related to uncontrolled, noncompressible, parenchymal hemorrhage from truncal injuries. The purpose of this study was to formulate a fibrin sealant foam (FSF) able to control severe parenchymal bleeding without compression or vascular control. MATERIALS AND METHODS FSF with high fibrinogen concentration (20 mg/mL) and low thrombin activity (5...

INTRODUCTION Some subjects have difficulty to integrate both visual and plantar inputs, showing at the same time a "postural blindness" and a Plantar Exteroceptive Inefficiency (PEI). The former corresponds to a better stability eyes closed (EC) than eyes open (EO), while the latter is defined as a better stability on foam than on firm ground. Clinical studies reported that a manipulation of ei...

The growth of biotechnology has led to renewed interest in the possibility of enriching valuable bioproducts using foam fractionation. This is a separation process in which surface active molecules are separated from a solution by sparging through bubbles of gas. Adsorption of such molecules at the gas/liquid interface causes enrichment in the foam formed above the liquid pool. Previous work ha...

Spray granulation is commonly used to improve the flow of drug formulation powders by adding liquid binders. We have discovered a new granulation process whereby liquid binders are added as aqueous foam. Initial experiments indicate that foam granulations require less binder than spray granulations, less water is added to the powder mass, rates of addition of foam can be greater than rates of a...