the aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine a from microemulsions, andtheir potential synergistic effect on the permeation enhancement. the transdermal deliveryof huperzine a from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...

The entangled history of Sciacharis Broun, 1983, a genus in which nearly 240 species were placed by Herbert Franz who has apparently never studied its type species, was recently summarized by Jałoszyński (2014a, b). A synonymy of Chatchamaenus Franz with Sciacharis s. str. was demonstrated, and Maorinus Franz, 1980 was placed as a subgenus of Sciacharis (Jałoszyński 2014a). Still, the systemati...

First, excised human skin obtained from abdominal plastic surgery is prepared for storage. In this procedure, the subcutaneous fatty tissue is separated from the outer skin layers, namely the epidermis and the dermis by a scalpel. Second, the epidermis is separated from the underlying dermis by a heat-separation technique. The separated epidermis will be used for subsequent permeation experimen...

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The formulation of the transdermal patch with fulvic acid (FA) on an emulsion basis using pluronic Kolliphor® p237 as a permeability enhancer was developed and studied for anti-inflammatory properties. FA isolated from peat in Nizhny Novgorod region Russia characterized potential active pharmaceutical ingredient. In vitro studies release patch, well penetration through acetyl cellulose membrane...

In the current study hollow microneedles (HMNs) were fabricated by means of vat polymerization method for transdermal delivery insulin. Two geometries HMNs designed in a Computer Aided Design (CAD) software namely, curved pyramid and syringe-like with Liquid Crystal Display (LCD) method. Dimensions determined quality features imaged scanning electron microscopy (SEM). Volumetric characterizatio...

OBJECTIVES The aim of the study was to prepare a sublingual formulation for piroxicam using a thermosensitive polymer and to evaluate its permeation through porcine sublingual mucosa. METHODS Formulation technique utilized the transition property of poloxamer from solution state at room temperature to gel state at oromucosal temperature (37 °C). The permeation of the drug was evaluated using ...

The transient development of electric-field distributions in a biased GaAs film after low density optical excitation is determined by measurements of Franz-Keldysh modulations with a time resolution of 100 fs. The experimental results are compared with theoretical calculations. The transient field is calculated with a drift-diffusion model. Our calculation of the dielectric function of GaAs inc...

An in vitro human percutaneous absorption study was conducted to assess the delivery of ketoprofen and testosterone from two base formulations, a Pluronic lecithin organogel and Pentravan Cream. Each formulation was applied to ex vivo human trunk skin (from three skin donors) on triplicate sections mounted onto Franz Diffusion Cells. Following a 5-mcL/cm2 applied dose, serial dermal receptor so...