Introduction: Leptin, secreted from adipose tissue may have some correlation with coronary artery disease according to some reports in literature. The mean concentration of plasma leptin in patients with normal and abnormal myocardial perfusion imaging (MPI) and relation of leptin levels, independently to abnormality in MPI after correction for body mass index (BMI) was evaluated. Methods...

Background: Leptin has been implicated in the differentiation and proliferation of hematopoietic cells. Leukemia inhibitory factor (LIF) may play an important role, along with Interleukin-6 (IL-6) and granulocyte colony stimulating factor (G- CSF), in the regulation of early hematopoietic stem cells. The aim of the study was to evaluate serum level of leptin, LIF, and IL-6 in myeloid leukemia p...

The hormone leptin, which is thought to be primarily produced by adipose tissue, is a polypeptide that was initially characterized by its ability to regulate food intake and energy metabolism. Leptin appears to signal the status of body energy stores to the brain, resulting in the regulation of food intake and whole-body energy expenditure. Subsequently, it was recognized as a cytokine with a w...

OBJECTIVE To determine the serum leptin levels in Pakistani pregnant subjects at the time of delivery and to ascertain the relationship between serum leptin levels and related variables (weight, body mass index, placental weight, gestational age, parity) at delivery. SETTING Lady Dufferin Hospital, and Ziauddin Hospital Karachi. METHODS Leptin concentration was measured in 110 subjects from...

The mechanisms initiating, regulating and sustaining the systemic stress response to a surgical injury have not all been identified yet. Recent studies point to the adipose tissue as a major endocrine system, the hormones of which influence energy homeostasis, glucose and lipid metabolism, vascular homeostasis, and immune response. Essential elements of this control system are leptin and ghreli...

Data from animal studies clearly indicate an association between leptin and hypertension; results of human studies are less concordant. We investigated the role of leptin in obesity-related higher blood pressure (BP) in Japanese Americans living in Hawaii and Japanese in Japan. Serum leptin and BP were examined by standardized methods in men and women ages 40 to 59 years from 2 population sampl...

OBJECTIVE To examine whether circulating leptin levels correlate with the severity of disease in patients with obstructive sleep apnea. DESIGN Prospective nonrandomized study. SETTING Referral sleep laboratory for patients with sleep-disordered breathing and biochemistry laboratory. Patients Thirty-two subjects (mean +/- SD age, 47 +/- 12 years) who were referred for suspected sleep apnea u...