OBJECTIVE Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients. Protein farnesylation, a posttranslational lipid modification of cysteine residues, has been emerging as a potential component of inflammatory response in sepsis. However, farnesylation has not yet been studie...

Isoprenoid inhibitors are being evaluated as agents for the treatment of cancer. Their antitumor activity is attributed to inhibition of post-translational modification of Ras, which is crucial for its translocation and attachment to the plasma membrane, and ultimate involvement in signal transduction. However, whether blocking of Ras is solely responsible for the observed antitumor activity is...

BACKGROUND Impairment of physical function and abnormal body composition are the major presentations in patients with chronic kidney disease (CKD). The aim of this study is to investigate the relationship between body composition and physical function in CKD patients. METHODS This cross-sectional study enrolled 172 of CKD stages 1-5 from February 2013 to September 2013. Handgrip strength (upp...

Recent advancements in Frontier Technologies and Innovations (FTI), including artificial intelligence, robotics, biotechnology have shown significant tremendous potentials for sustainable development globally. Despite this, Africa appears to be unprepared equitably use or adopt these technological innovations. Evidence has that the ongoing global growth FTI negatively impacts with multifaceted ...

Substantial neutral atoms can tunnel to excited states in an intense laser field and subsequently generate coherent emission through free induction decay. We experimentally observe enhanced the harmonic slightly below threshold, which is consistent with decay of Rydberg produced by frustrated tunnelling ionization (FTI) process. further find that intensity significantly depends on chirp pulses....

In order to maintain and improve the quality of website Faculty Industrial Technology (FTI), Universitas Islam Indonesia (UII), usability testing is performed on using System Usability Scale (SUS). This study aims evaluate analyze user experience FTI UII so that faculty can follow up it. Respondents consisted 41 active students. were asked complete scenarios while being watched by examiners. Th...

BACKGROUND Level of the testosterone in a man's life span is very important. Studies on the serum testosterone concentrations in different age groups of healthy men were controversial. The aim of this study was to investigate dynamic changes of serum reproductive hormones with aging in healthy Chinese male and to compare its correlation with age. METHODS Total of 1,093 healthy Chinese men fro...

In order to identify small G protein (s) which contributes to the proliferation of vascular smooth muscle cells (VSMCs), we examined the effect of an HMG-CoA reductase inhibitor (cerivastatin), a farnesyltransferase inhibitor (FTI-277), a geranyl geranyl transferase inhibitor (GGTI-286) and a Rho kinase inhibitor (Y-27632) on the proliferation of cultured rat VSMCs stimulated with 20ng/ml plate...

High amounts of nitric oxide (NO) produced by activated macrophages or NO donors are required to induce cytotoxicity and apoptosis in pathogens and tumor cells. High concentrations of NO may lead to nonspecific toxicity thereby limiting the use of NO donors in the treatment of cancer. In this study, we tested the possibility of potentiating the apoptotic action of NO in a human breast cancer ce...