BACKGROUND A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to examine TG2 expression and its clinicopathologic significance in a large number of human clear cell RCCs (CCRCCs). METHODS We analyzed 638 CCRCC patients who underwent partial or radical nephrectomy between 19...

DNA sequencing revealed that mutations in SETD2 occur in 3% to 12% of clear-cell renal cell carcinoma (ccRCC) cases and are associated with poor clinical outcome. In this study, we used an immunohistochemistry (IHC) assay to evaluate the impact of SETD2 loss, with expression of H3K36me3, a nonredundantly histone modification by SETD2, on recurrence and survival of nonmetastatic ccRCC patients a...

abstract p u rpose: this study aimed to correlation between the grading stenosis and the start back screening tool (sbst) in patients diagnosed with lumbar central canal stenosis (lccs). methods: in a prospective clinical study, a total of 269 patients with lccs were asked to respond to the questionnaire at their first visits. grading of lccs on mri was determined and also the severities of the...

the purpose of this research is to prioritize the indexes of discretion, heterogeny and autogeny factors in order to analyze and evaluate their readiness for ideal situation of central bank of the islamic republic of iran (cbi). this research is an exploratory kind and in terms of method is a survey kind. the data collection tool is questionnaire. after two delphi cycles, in final questionnaire...

background: gliomas are the most common primary neoplasms of the central nervous system. relative cerebral blood volume (rcbv) could estimate high-grade gliomas computed with dynamic susceptibility contrast mr imaging which it is artificially lowered by contrast extravasation through a disrupted blood-brain barrier. objectives: our intent was to clarify the usefulness of diffusion-weighted magn...

This paper presents a modeling scheme for objects containing multiple materials or functionally graded materials (FGM), i.e. heterogeneous objects. The material composition variations under this modeling scheme are controlled by some reference features termed as “grading sources”. The “grading source” gathers the type of grading, position of grading and a material grading function for controlli...

BACKGROUND Diabetes is a chronic disease characterized by impaired fasting blood glucose that leads to disturbances in various organs. In this study, we evaluated relationships between tumor size and grade in a population of diabetic and non-diabetic patients with renal cell carcinoma. MATERIALS AND METHODS Between 2007-2013, in our clinic radical nephrectomy performed to 310 patients for ren...

OBJECTIVES The clinical significance of positive surgical margin (PSM) after a Nephron Sparing Surgery (NSS) is controversial. The aim of this study is to evaluate the association between PSM and the risk of disease recurrence in patients with pT1 kidney tumors who underwent NSS. MATERIALS AND METHODS Retrospective cohort study. A total of 314 patients submitted to a NSS due to stage pT1 rena...

AIM To investigate the prognostic significance of certain clinical and pathological factors of renal cell cancer. MATERIALS AND METHODS One hundred and fourteen patients who underwent radical nephrectomy between 1996 and 2011 in our hospital were examined. Parameters including age, gender, mode of presentation, hematological and pathological parameters were evaluated for their role as predict...