General biological databases that store basic information on genome, transcriptome, and proteome are indispensable sequence discovery resources. However, they are not necessarily useful for inferring functions of proteins. To see this, we observe that SWISS-PROT —a protein knowledgebase containing curated protein sequences and functional information on domains and diseases—has grown a mere 26-f...

Our group has developed a series of iron-based asymmetric transfer hydrogenation (ATH) catalysts for the reduction of polar double bonds. The activation of the precatalysts as well as the catalytic mechanism have been thoroughly investigated, but the decomposition pathways of these systems are poorly understood. Herein, we report a study of the deactivation pathways for an iron ATH catalyst und...

Fluctuations in population size are in many cases undesirable, as they can induce outbreaks and extinctions or impede the optimal management of populations. We propose the strategy of adaptive threshold harvesting (ATH) to control fluctuations in population size. In this strategy, the population is harvested whenever population size has grown beyond a certain proportion in comparison to the pre...

This lecture describes methods for analyzing networks in terms of their motif content. Network motifs are defined as ”recurring patterns of interactions that are significantly over-represented”. The motivation for analyzing the motif content of the network lies in the basic assumption that the over-representation of a certain motif in a network indicates it has some functional importance. Thus,...