Activation of both PAR-1 (proteinase-activated receptor-1) and PAR-2 resulted in release of the chemokine GRO (growth-regulated oncogene)/CINC-1 (cytokine-induced neutrophil chemoattractant-1), a functional counterpart of human interleukin-8, from rat astrocytes. Here, we investigate whether the two PAR receptor subtypes can signal separately. PAR-2-induced GRO/CINC-1 release was independent of...

The prostate apoptosis response-4 (par-4) gene was identified by differential screening for genes that are upregulated when prostate cancer cells are induced to undergo apoptosis. The par-4 gene is induced by apoptotic signals but not by growth-arresting, necrotic, or growth-stimulatory signals. The deduced amino acid sequence of par-4 predicts a protein with a leucine zipper domain at its carb...

l'utilisation des fluctuations statistiques des signaux analogiques fournis par les detecte urs neutroniques pour ameliorer la discrimination neutron _gamma a ete suggeree pour la premiere fois par «lichtenstein» en 1955. un detecteur soumis a'un rayonnemet libere, en moyenne, n impultions par seconde caracterisees par leur charge q. si l' on integre ces impultions dans une cellu...

eperisone hydrochloride is a skeletal muscle relaxant and paracetamol is cyclooxygenase inhibitor. these drugs in combination are used as antispasmodics. a simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of eperisone hydrochloride and paracetamol in tablet dosage form. in rp-hplc method separati...

la question de l’interaction entre le lecteur et le personnage est cruciale en toute étude en littérature fictionnelle. pourtant, malgré l’intérêt que les chercheurs portent depuis longtemps à l’examen de cette relation, celle-ci n’a été que rarement l’objet d’une étude méthodique. c’est pour combler ce manque que vincent jouve propose sa théorisation sur « l’effet-personnage ». le modèle prése...

Wireless networks have experienced drastic evolutions in the last few years. While many aspects related to “single cell” wireless networks were already resolved, wireless multihop networks still suffer poor performances and limited capacities. This thesis aims at providing acceptable quality of service in terms of throughput and loss ratio to end users in various wireless multihop environments....

Covering the apex of intestinal cells, microvilli are microscopic membrane protrusions structured by a network of actin filaments organized by actin binding proteins. The objective of my thesis consists on investigating how the microvillar actin binding proteins regulate two key features of these organelles: their functionality and plasticity. From a structural point of view, the actin filament...

Photosynthetically active radiation (PAR) is a key input parameter for almost all terrestrial ecosystem models, but the spatial resolution of current PAR products is too coarse to satisfy regional application requirements. In this paper, we present an operational system for PAR retrieval from MODIS data that is based on an idea proposed by [Liang, S., Zheng, T., Liu, R., Fang, H., Tsay, S. -C.,...

A polarity complex of PAR-3, PAR-6, and atypical protein kinase C (aPKC) functions in various cell polarization events. PAR-3 directly interacts with Tiam1/Taim2 (STEF), Rac1-specific guanine nucleotide exchange factors, and forms a complex with aPKC-PAR-6-Cdc42*GTP, leading to Rac1 activation. RhoA antagonizes Rac1 in certain types of cells. However, the relationship between RhoA and the PAR c...