The mouse mammary tumor virus (MMTV) gag-pro frameshifting pseudoknot is an H-type RNA pseudoknot that contains an unpaired adenosine (A14) at the junction of the two helical stems required for efficient frameshifting activity. The thermodynamics of folding of the MMTV vpk pseudoknot have been compared with a structurally homologous mutant RNA containing a G x U to G-C substitution at the helic...

During normal epithelial maturation, actin and α-actinin-4 accumulated at the cell junction over a period of several days (Fig. 1 A). By the second day post-confluence (2 dpc), most canonical junctional components, E-cadherin, α-catenin, and β-catenin, p120-catenin, and ZO-1, were already present (Fig. 1, A and B). However, vinculin has not been targeted at this early stage of junction developm...

The resonant tunneling model is the simplest for describing electronic transport through nanoscale objects like individual molecules. A complete understanding includes not only charge but also thermal and their intricate interplay. Key linear response observables are electrical conductance G Seebeck coefficient S. Here we present experiments on unspecified tunnel junctions molecular that uncove...

Targeting the interface between DNA quadruplex and duplex regions by small molecules holds significant promise in both therapeutics nanotechnology. Herein, a new pharmacophore is reported, which selectively binds with high affinity to quadruplex–duplex junctions, while presenting poorer for G-quadruplex or alone. Ligands complying reported exhibit selectivity including one observed HIV-1 LTR-II...

Hybrid superconductor/graphene (SC/g) junctions are excellent candidates for investigating correlations between Cooper pairs and quantum Hall (QH) edge modes. Experimental studies challenging as Andreev reflections extremely sensitive to junction disorder high magnetic fields required form QH states. We fabricated low-resistance SC/g interfaces, composed of graphene contacted with NbN a barrier...

T-cell responses to viruses are still poorly investigated in lower vertebrates. In rainbow trout, a specific clonal expansion of T cells in response to infection with viral haemorrhagic septicaemia virus (VHSV) was recently identified. Expanded T-cell clones expressed a unique 8 aa Vbeta4-Jbeta1 junction (SSGDSYSE) in different individuals, reminiscent of a typical public response. To get furth...

CASE REPORT THE ORTHOPAEDIC JOURNAL AT HARVARD MEDICAL SCHOOL 58 Musculotendinous Junction Tears of the Subscapularis: A Report of Two Cases Stuart D. Kinsella, MD, MS1 Sean Michael Rider, MD1 Emily M. Brook, BA2 Jon J.P. Warner, MD1 Elizabeth G. Matzkin, MD2

Neuromuscular transmission of excitation in invertebrates has been studied extensively by many investigators (cf. Bullock & Horridge, 1963). Miniature inhibitory junction potentials (m.i.j.p.s) and miniature excitatory junction potentials (m.e.j.p.s) could be recorded from the longitudinal layer of the somatic muscle in the earthworm. Field stimulation to the peripheral nerves elicited inhibito...

Electrostatically linked ferrocene junctions were assembled and their conductance was investigated on the level of individual molecules by means of an electrochemical mechanical break junction. Conductance histograms of repeatedly formed molecular junctions showed peaks at multiples of 3.4 × 10(-5) G(0), which is one order of magnitude smaller than the conductance reported for covalently linked...