Various cationic polypeptides of linear or highly branched structures were synthesized by introducing tertiary or quaternary ammonium groups and hydroxyl groups to poly(L-lysine) (PL) or polyamideamine (PAMAM) dendrimers. These polycations were mixed with plasmid DNA to form polyplexes and subjected to in vitro gene introduction experiment. The transient gene expression was greatly affected by ...

Photodynamic therapy (PDT) involves the action of photons on photosensitive molecules, where atomic oxygen or OH(-) molecular species are locally released on pathogenic human cells, which are mainly carcinogenic, thus causing cell necrosis. The efficacy of PDT depends on the local nanothermodynamic conditions near the cell/nanodrug system that control both the level of intracellular translocati...

Biological molecules and intracellular structures operate at the nanoscale; therefore, development of nanomedicines shows great promise for the treatment of disease by using targeted drug delivery and gene therapies. PAMAM dendrimers, which are highly branched polymers with low polydispersity and high functionality, provide an ideal architecture for construction of effective drug carriers, gene...

Poly(amidoamine)(PAMAM) dendrimers with a cinnamoyl shell were prepared by reacting full generation PAMAM dendrimers (G53.0) with 2-chloroethanol and cinnamoyl chloride, which resulted in densely packed polymerizable unsaturated groups on the periphery. The cinnamoyl shell of the dendrimers dimerized when irradiated under a UV light by using 5-nitroacenaphthylene as an initiator in dilute dimet...

The development of effective drug delivery systems is a crusial task for modern medicine. main problem the occurrence non-specific toxicity leading to undesirable side effects in vivo. This article aims at reviewing resent research on polyamidoamine (PAMAM) dendrimers results show that PAMAM and modified nanoparticles depends both characteristics particles themselves (size, generation surface c...

Functionalisation of PAMAM dendrimers with a small number of thiol groups makes them good ligands for CdSe/ZnSe nanoparticles; the particles coated with thiolated dendrimers have good cell permeability and are potent transfection agents.

This study reveals novel mechanisms and potential biomarkers of nanopolymer toxicity (polystyrene nanoplastics PAMAM dendrimers) singly in combination a relevant aquatic primary producer, essential for sustaining the food chain.

substrates Michal Borkovec Email. [email protected] July 31, 2012 Direct link www.colloid.ch/dendrimers Since their synthesis by Vögtle and Tomalia in the eighties, dendrimers have developed into an very interesting class of novel polymeric materials. Potential applications include surface patterning, synthesis of nanoparticles, or gene delivery. Our research group was much involved in t...

The structure of copper(II) complexes formed with triethanolamine (TEA) core poly(amidoamine) (PAMAM) dendrimers from generation 0 (G0) to 4 (G4) were investigated by the electron paramagnetic resonance (EPR) technique and molecular simulations. Different square planar coordination modes were detected as a function of copper(II) concentration, whose dynamic evolution relates to the high structu...

We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated. Conjugation of the PAMAM dendrimer to the surface of th...