BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited human enzyme defect. This deficiency provides some protection from clinical malaria, but it can also cause haemolysis after administration of drugs with oxidant properties. METHODS The safety of chlorproguanil-dapsone+artesunate (CD+A) and amodiaquine+sulphadoxine-pyrimethamine (AQ+SP) for the treatmen...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzyme defect in humans, caused by a mutation X-linked gene encoding G6PD. The G6PD plays an important role to produced reducing agents which maintain reduced glutathione through pentose phosphate pathway. On ingestion of Faba Bean (Vicia faba L.), vicine and convicine are hydrolyzed β -glucosidase divicine isoura...

Introduction.Neonatal sepsis is a disease process, which represents the systemic response of bacteria entering the bloodstream during the first 28 days of life. The prevalence of sepsis is higher in male infants than in females, but the exact cause is unknown. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway, which leads to the production of NADPH. NADPH is...

In Iran, according to WHO, the prevalence of G6PD enzyme deficiency is 10-14.9%[1]. An epidemiological study showed in the Fars province (southern Iran) 12% of males and 1.8% of females are G6PD deficient[2]. Initial neutrophil bactericidal activity depends on oxygen free radical production by the NADPH oxidase. In G6PD deficient state, decreasing the production of neutrophil NADPH has been rep...

The activity of red blood cell Glucose 6-phosphate dehydrogenase (G6PD) in one hundred and twenty six healthy male individuals who are Nigerians residing in Jos was evaluated. The enzyme activity was determined quantitatively by spectrophotometer assay method. The activity of red cell G6PD enzyme was subnormal in 20 % of the population studied. This agrees with previous report of the prevalence...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic enzyme defect present in many people from African, Middle Eastern, Mediterranean and Asian countries. Individuals with the enzyme deficiency may remain asymptomatic, develop an acute haemolytic crises to infections or Fava beans, neonatal jaundice or chronic non-spherocytic haemolytic anaemia. Electrophoretic mobility may b...

Glucose-6-Phosphate Dehydrogenase (G6PD) is a cytosolic enzyme which its main function is to produce NADPH in the red blood cells by controlling the step from Glucose-6-Phosphate to 6-Phospho gluconate in the pentose phosphate pathway. G6PD deficiency is the most common X-chromosome linked hereditary enzymopathy in the world, that result in reduced enzyme activity and more than 125 different mu...

glucose 6-phosphate dehydrogenase (g6pd) deficiency is an enzyme deficiency of the red blood cells and the most important disease of hexose monophosphate pathway. the role of hemolysis in the pathophysiology of neonatal jaundice due to g6pd deficiency is in contencious. our aim is to study the role of hemolysis in neonatal jaundice associated with g6pd deficiency. this prospective descriptive s...

OBJECTIVE Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect. G6PD plays a key role in the pentose phosphate pathway, which is a major source of nicotinamide adenine dinucleotide phosphate (NADPH). NADPH provides the reducing equivalents for oxidation-reduction reductions involved in protecting against the toxicity of reactive oxygen species such as H2O2....

Background: Glucose-6 phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme deficiency of red blood cells involving the enzyme pathway of hexose monophosphate. This study was conducted to examine the effect of vitamin E and folic acid on the improvement of acute hemolysis caused by the G6PD deficiency in patients referred to 17 Shahrivar Hospital, Rasht. Materials and M...