نتایج جستجو برای: gamma coronavirus

تعداد نتایج: 163120  

2012
Taylor Heald-Sargent Tom Gallagher

Coronavirus-cell entry programs involve virus-cell membrane fusions mediated by viral spike (S) proteins. Coronavirus S proteins acquire membrane fusion competence by receptor interactions, proteolysis, and acidification in endosomes. This review describes our current understanding of the S proteins, their interactions with and their responses to these entry triggers. We focus on receptors and ...

Journal: :Blood 2007
Luisa Cervantes-Barragan Roland Züst Friedemann Weber Martin Spiegel Karl S Lang Shizuo Akira Volker Thiel Burkhard Ludewig

This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following enc...

Journal: :Journal of clinical microbiology 1979
S Dea R S Roy M E Begin

A counterimmunoelectroosmophoresis (CIE) technique is described for the detection of calf diarrhea coronavirus antigens in intestinal contents. The antibody reagent was prepared in rabbits against the Nebraska calf diarrhea coronavirus adapted to Vero cells and purified by density gradient centrifugation. The method was applied to intestinal contents of diarrheic and normal calves and compared ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Caroline Lassnig Carlos M Sanchez Monika Egerbacher Ingrid Walter Susanne Majer Thomas Kolbe Pilar Pallares Luis Enjuanes Mathias Müller

Human coronavirus (HCoV) 229E is a group 1 coronavirus and is specific to humans. So far, no animal model is available to study the pathogenesis of infection by HCoV-229E. We show here that the expression of aminopeptidase N (APN, also termed CD13), the receptor for HCoV-229E, is required but not sufficient to confer susceptibility in vivo. HCoV-229E infection was facilitated by crossing APN tr...

2016
To Sing Fung Ying Liao Ding Xiang Liu

Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is in...

2004
Hong Luo Jingchu Luo

A dedicated anti-SARS bioinformatics web site was setup in April 2003 at the Centre of bioinformatics (CBI), Peking University (http://antisars.cbi.pku.edu.cn/). A special bioinformatics platform was constructed to analyse the sequence and structure data of SARS coronavirus and other viruses. A total file of 32 SARS coronavirus genome sequences was retrieved from GenBank and mismatches in 30 si...

Journal: :Journal of clinical microbiology 1980
M R Macnaughton B J Thomas H A Davies S Patterson

The replication of human coronavirus strain 229E was observed by using indirect immunofluorescence in infected monolayers of MRC continuous cells. By 8 h after infection, bright cytoplasmic fluorescence was detected in cells infected with human coronavirus 229E. Discrete foci of infection were observed from 8 to 16 h after infection in cells infected with high dilutions of human coronavirus 229...

Journal: :Journal of virology 2008
Kathie A Mihindukulasuriya Guang Wu Judy St Leger Robert W Nordhausen David Wang

The emergence of viruses such as severe acute respiratory syndrome coronavirus and Nipah virus has underscored the role of animal reservoirs in human disease and the need for reservoir surveillance. Here, we used a panviral DNA microarray to investigate the death of a captive beluga whale in an aquatic park. A highly divergent coronavirus, tentatively named coronavirus SW1, was identified in li...

2005
Ajai A. Dandekar Katherine O’Malley Stanley Perlman

T cells mediate demyelination in athymic (nude) mice infected with the neurotropic coronavirus mouse hepatitis virus strain JHM. Now, we show that these cells also mediate the same process in mice lacking T cells (T-cell receptor -deficient [TCR / ] mice) and demyelination is gamma interferon (IFN) dependent. Most strikingly, our results also show a major role for NKG2D, expressed on T cells, i...

Journal: :The Journal of general virology 2003
Volker Thiel Konstantin A Ivanov Akos Putics Tobias Hertzig Barbara Schelle Sonja Bayer Benedikt Weissbrich Eric J Snijder Holger Rabenau Hans Wilhelm Doerr Alexander E Gorbalenya John Ziebuhr

A novel coronavirus is the causative agent of the current epidemic of severe acute respiratory syndrome (SARS). Coronaviruses are exceptionally large RNA viruses and employ complex regulatory mechanisms to express their genomes. Here, we determined the sequence of SARS coronavirus (SARS-CoV), isolate Frankfurt 1, and characterized key RNA elements and protein functions involved in viral genome ...

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