diosmin, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low dissolution rate. in this study, β-cyclodextrin (βcd) and 2-hydroxypropyl-β-cyclodextrin (hpβcd) were obtained to improve the solubility and dissolution rate of diosmin. phase solubility studies of diosmin with βcd and hpβcd in distilled water were conducted to charac...

New psychoactive substances (NPS) count as substances, which are slightly modified compared to illicit drugs regarding their chemical structure circumvent law. Compared classical such heroin, cocaine, or amphetamine, they show similar effects, however, because of novelty there is few knowledge about side effects toxicity. NPS available different substance classes, among them chiral novel deriva...

Due to their unique structural, physical and chemical properties, cyclodextrins derivatives have been of great interest scientists researchers in both academia industry for over a century. Many the industrial applications arisen from ability encapsulate, either partially or fully, other molecules, especially organic compounds. Cyclodextrins are non-toxic oligopolymers glucose that help increase...

The Cyclodextrins are of particular interest and importance in the field of inclusion and the formation of molecular complex. The aim of this work is to search by various techniques, among others: the molecular docking, the inclusion techniques, and complexations (Tail-Thread, Thread-Thread, Tail-Tail) of conformations (geometric parameters) to form inclusion complexes of beta-cyclodextrin with...

Poly[2]rotaxane and supramolecular assembly have been prepared by modified cyclodextrins bearing an adamantyl group in an aqueous medium.

Tocotrienol, a member of the vitamin E family of compounds, is currently receiving increased attention owing to its highly promising anticancer effects. However, its potential in cancer therapy is limited by its poor bioavailability and its inability to specifically reach tumors at therapeutic concentrations after intravenous administration. In order to address these problems, various delivery ...

Chiroptical spectroscopy is one of the most developing areas of chiral analysis which role has been enhanced in recent years. In the thesis new applications of circular dichroism (CD) and optical rotatory dispersion (ORD) methods are presented via some examples. A quick and accurate CD spectroscopic method was developed for the simultaneous determination of ethisterone and its delta5-isomer (de...

Deuterium NMR in an aqueous non-chiral liquid crystal allows the discrimination of enantiomers through their ordering inside beta-cyclodextrins.

The use of natural carotenoids as food colorants is an important trend innovation in the industry due to their low toxicity, potential bio-functional ingredients, and increasing demand for organic foods. Despite these benefits, inclusion matrices presents multiple challenges related stability water solubility. present review covers main concepts background carotenoid complex formation cyclodext...