3-Amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) is a bioreductive anticancer drug which has a high selective toxicity to hypoxic cells. We have characterized the DNA and chromosome damage in wild-type Chinese hamster ovary (CHO) cells and mutant XR-1 cells after exposure to SR 4233 under hypoxia and compared it to the damage produced by ionizing radiation (gamma-rays). Using the technique of ...

Background: Ionizing radiation induces the production of reactive oxygen species (ROS), which play an important causative role in cell death. The aim of this study was to investigate the protective effects of sulfated derivatives of neutral polysaccharides extracted from Auricularia auricular (SNAAP). Materials and Methods: Whole blood samples from healthy donors treated with SNAAP at differen...

Background: Ionizing radiation induces the production of reactive oxygen species (ROS), which play an important causative role in cell death. Wholebody exposure of mice to gamma radiation leads to diminution of tissue antioxidant defense systems increases the peroxidative damage to membrane lipids and damages the haematopoietic and gastrointestinal systems. Tempol (TPL), a cell membranep...

A brief survey of plastic scintillators for various radiation measurement applications is presented here. The utility of plastic scintillators for practical applications such as gamma radiation monitoring, real-time radioisotope detection and screening is evaluated in laboratory and field measurements. This study also reports results of Monte Carlo-type predictive responses of common plastic sc...

There is considerable demand for structural health monitoring (SHM) at locations where there are substantial radiation fields such as nuclear reactor components, dry cask storage canister, irradiated fuel assemblies, etc. Piezoelectric wafer active sensors (PWAS) have been emerged as one of the major SHM sensing technologies. In order to use PWAS to perform SHM in nuclear environment, radiation...

Background: During radiation therapy, stromal cells surrounding the tumor (e.g mesenchymal stem cells) may affect the treatment outcomes. We aimed to investigate the effects of gamma radiation on the mRNA expression of cytokines, DNA damage and population doubling time (PDT) of adipose-derived mesenchymal stem cells (ASCs). Material and methods: ASCs were enzymatically extracted from breast tis...

We report measurements of background gamma radiation levels on six islands in the northern Marshall Islands (Enewetak, Medren, and Runit onEnewetak Atoll; Bikini and Nam on Bikini Atoll; and Rongelap on Rongelap Atoll). Measurable excess radiation could be expected from the decay of (137)Cs produced by the US nuclear testing program there from 1946 to 1958. These recordings are of relevance to ...

background: rad51 is a protein with critical role in double strand break repair. down-regulation of this protein has a significant effect in radiosensitivity of some cell lines like prostate carcinoma. compared to monolayer cell culture model, the spheroids are more resistant to radiation. the aim of the current study was to determine the rad51 protein level in du145 spheroids, and monolayer ce...

 ABSTRACTBackground: There are relatively rich uranium mines in regions of Saghand and Bafgh in Yazd province. This survey was carried out to provide a map of ambient gamma radiation of Yazd province and the probable effects of the existence of these mines on background radiation dose rates.Materials and Methods: The measurements of the outdoor and indoor–environmental exposures (including cosm...