Gamma (gamma)-irradiation is finding increasing use in the sterilization of pharmaceutical products. However, irradiation also might affect the performance of drug delivery systems. In this study, the influence of gamma-irradiation on the characteristics of chitosan microparticles was investigated. The diclofenac sodium was incorporated into chitosan microparticles by spray-drying method. The c...

The possible enhancement, using immunotherapy with interferon-gamma (IFN-gamma), combined with conventional antifungal therapy, was studied in a murine model of systemic cryptococcosis. Four weeks after intravenous challenge, infection was quantified in brains and livers of survivors. Groups received IFN-gamma every other day beginning 7 days before (prophylaxis), or after infection (14 doses),...

Abstract. Particular interest now centers on the preparation of steril-unit dose preparations. When preparations are purified from microorganisms using classic sterilization techniques, serious degradations may occur especially in temperature sensitive drugs and drug active components. Sultamicillin is the tosylate salt of double ester of sulbactam plus ampicillin. Sultamicillin tosylate (SULT)...

Gamma irradiation sterilization (gamma-irradiation) fragments and denatures collagen, drastically decreasing critical physical properties. Our goal was to maintain strength and stability of gamma-irradiated collagen by adding glucose, which in theory can initiate crosslink formation in collagen during exposure to gamma-irradiation. Collagen films prepared with and without glucose were gamma-irr...