Cystathionine has been reported to undergo enzymatic changes leading to the formation of seven membered cyclic products (Ricci, G., Santoro, L., Achilli, M., Matarese, R. M., Nardini, M., and Cavallini, D. (1983) J. Biol. Chem. 258, 10511-10517; Cavallini, D., Costa, M., Pensa, B., and Coccia, R. (1985) Biochem. Int. 10, 641-646). Gas-chromatographic and mass-spectrometric evidence reported in...

Sir,—MacDonald and Mackenzie (1976) reported an alinear relationship between peak height and halothane concentration when measuring halothane (0.2—4.0%) with a gas chromatograph equipped with a flame ionization detector. Alinearity persisted when the sample loop size was reduced from 2 ml to 0.1 ml, and a linear response was obtained only when the flame ionization detector was replaced with a k...

We describe a modified gas-chromatographic method for acetate in serum or plasma, intended for use in the investigation of acetate intolerance in hemodialysis patients. The assay may be adapted for use with a single-column gas chromatograph equipped with a flame ionization detector. The analysis, made isothermally, requires only 0.5 ml of plasma or serum. Only one deproteinizing step is require...

A method for the determination of lactic acid concentration in blood by gas chromatography is described. Lactic acid in a protein-free filtrate is oxidized by ceric sulfate to acetaldehyde. The latter compound is introduced into the gas chromatographic column by vapor phase injection, and is quantitatively measured within 3 mm. The method is specific, precise, and not affected by compounds that...

A gas chromatographic method for the quantitative determination of glutethimide was developed. This method was applied to samples obtained from patients who were comatose because of acute glutethimide intoxication. The results obtained from this procedure were compared with those obtained by using an ultraviolet method. The patients’ clinical conditions were assessed and correlated with the blo...

Inverse gas chromatography (IGC) represents a unique refinement of a classic chromatographic method has the potential to unlock some of the more difficult to measure physicochemical properties of pharmaceutical materials such as powder surface energies, acid/base/polar functionality of surfaces, diffusion kinetics, solubility parameters, surface heterogeneity and phase transition temperatures/h...