A sensitive static headspace gas chromatographic method was developed and validated for the determination of residual epichlorohydrin (ECH) in sevelamer hydrochloride (SVH) drug substance. This method utilized a Phenomenex Zebron ZB-WAX GC column, helium as carrier gas with flame ionization detection. The critical experimental parameters, such as, headspace vial incubation time and incubation t...

Two retention time locked methods for the analysis of essential oil compounds are described. The first method is a gas chromatography/flame ionization detector method using a 50 m × 320 μm id × 1.05 μm HP-5 column. The second method is a gas chromatography/mass spectrometry method using a 30 m × 250 μm id × 0.25 μm HP-5MS column. Retention times of approximately 400 essential compounds were mea...

A capillary gas chromatography method using a flame ionization detector has been developed for the trace analysis of allylamine (AA) in sevelamer hydrochloride (SVH) and sevelamer carbonate (SVC) drug substances. The method utilized a mega bore capillary column DB-CAM (30 m × 0.53 mm × 1.0 μm) with a bonded and cross-linked, base-deactivated polyethylene glycol stationary phase and was validate...

Simple, cheap and green protocol for effective conversion of alcohols to corresponding carbonyl compounds in the presence of H14[NaP5W30O110] and ammonium nitrate is reported. The products were characterized by FT-IR and comparison of their physical properties with those reported in the literatures. The progress of the reaction was monitored by thin layer chromatography (TLC) technique. The ali...

A preparative gas chromatography (pGC) method was developed for the separation of volatile components from the methanol extract of Curcuma rhizome. The compounds were separated on a stainless steel column packed with 10% OV-101 (3 m × 6 mm, i.d.), and then, the effluent was split into two gas flows. One percent of the effluent passed to the flame ionization detector (FID) for detection and the ...

We report a micro-scale procedure for determination of theophylline by use of gas chromatography with nitrogen-sensitive detection. The procedure requires only 10 mul of serum, plasma, or saliva. This sample size makes the determination especially appropriate for monitoring in a pediatric population. With the sample volume used, background interference is equivalent to about 0.1 mg/liter and 0....

Adsorbent tube samples are collected by drawing workplace air through either coconut shell charcoal or Anasorb 747 tubes with personal sampling pumps. Diffusive samples are collected by exposing either 3M 3520 Organic Vapor Monitors (OVMs) or SKC 575-002 Passive Samplers to workplace air. Samples are desorbed with 60/40 (v/v) N,N-dimethylformamide/carbon disulfide (DMF/CS2) and analyzed by gas ...

This study describes optimization of headspace solid phase microextraction followed by gas chromatography equipped with a flame ionization detector for toluene at trace level in spiked urine. The parameters affecting the extraction and gas chromatographic determination of analytes were studied: extraction time and temperature; desorption time and temperature; addition of NaCl; and pH, volume an...

A simple solvent extraction method was used to analyze alcohol-based hand rubs (ABHRs) using gas chromatography with a flame ionization detector. 79 samples including 68 liquid and 11-gelled ABHRs were analyzed in the Food Drug Laboratories Research Center of Mashhad, Iran. 17 had methanol, 50 correct percentage alcohol (60-80%), 12 incorrect (<60%). The RSD% ethanol, isopropanol as 2.28, 2....

The gas chromatographic analysis of fatty acids has attracted considerable interest. In this analysis, the common derivatives of fatty acids, such as fatty acid methyl esters, can be detected using a flame ionization detector and the mass spectra can indicate the true structure of fatty acids. This paper reviews gas chromatographic methods for obtaining fatty acids from marine organisms. The st...