It has been shown that those factors which affect gastric acid secretion through the ventromedial and lateral nuclei of hypothalamus, can significantly alter centrally-mediated secretion. There is much evidence that glucose is among these factors that through a central mechanism can decrease induced acid secretion. It appears that this effect is mediated through glucose-sensitive neurons within...

AIM To investigate the effects of nesfatin-1 on gastric function in obese rats. METHODS The obese rat model was induced by a high-fat diet. The gastric emptying rate and gastric acid secretory capacity of the rats were determined after treatment with different drug concentrations of nesfatin-1 and administration routes. Based on this, the expression of H+/K+-ATPase was measured using RT-PCR a...

The effect of intraduodenal acid on pentagastrin-stimulated gastric secretion has been investigated in 12 normal subjects and 23 patients with chronic duodenal ulceration. Plasma secretin levels were monitored during each test using a highly sensitive radioimmunoassay. Significant inhibition of gastric secretion occurred in the normal subjects and duodenal ulcer patients. A significant rise in ...

Nigella sativa (NS) has been shown to have antioxidant, anti-inflammatory and antiulcer activities in different conditions. The present work was done to investigate the possible effects of Nigella sativa aqueous extracts (NS) on gastric acid secretion in isolated rat stomach. Gastric acid secretion was measured in the isolated rat stomach preparation. The results obtained in vitro experiments s...

about 1.5-6 % of the patients with gastric and duodenal erosions admitted to i.c.u. are prone to gastrointestinal (g.i.) bleeding with its ensuing complications. routine prophylaxis with h2-blockers and anti-acid has been used in these high risk patients for decades. in this study we evaluated the effect of p.o omeprazole, a potent acid inhibitor with prolong effects on gastric ph.  patients wi...

Motilin and ghrelin constitute a peptide family, and these hormones are important for the regulation of gastrointestinal motility. In this study, we examined the effect of motilin and ghrelin on gastric acid secretion in anesthetized suncus (house musk shrew, Suncus murinus), a ghrelin- and motilin-producing mammal. We first established a gastric lumen-perfusion system in the suncus and confirm...

The effect of water temperature during restraint and water-immersion stress (RWIS) on gastric regional blood flow, acid secretion and ulcer formation were compared to those of restraint stress (RS) alone in rats. RS had no effect on the gastric regional blood flow. In contrast, the gastric regional blood flow was significantly decreased by RWIS. A water temperature dependent reduction of gastri...

TO THE EDITOR: We read with great interest the report by Nonaka et al about the effects of histamine-2 receptor antagonists and proton pump inhibitors (PPIs) on gastric emptying. The authors clearly showed that a single intravenous injection of famotidine and omeprazole had no effects on gastric emptying using the continuous real-time C breath test (Breath ID System) in a randomized placebo-con...

OBJECTIVE To measure pH, volatile fatty acid (VFA) concentrations, and lactate concentrations in stomach contents and determine number and severity of gastric lesions in horses fed bromegrass hay and alfalfa hay-grain diets. ANIMALS Six 7-year-old horses. PROCEDURE A gastric cannula was inserted in each horse. Horses were fed each diet, using a randomized crossover design. Stomach contents ...

BACKGROUND & AIMS Gastric acid is known to contribute to ulcer pain, but the mechanisms of gastric chemonociception are poorly understood. This study set out to investigate the pathways and mechanisms by which gastric acid challenge is signaled to the brain. METHODS Neuronal excitation in the rat brainstem and spinal cord after intragastric administration of HCl (0.35-0.7 mol/L) was examined ...