Morinda citrifolia is a member of the Rubiaceae. It is a Shrub or compacted to twisted small tree up to 8 m high with square stems and large stipules between nodes and petioles. Leaves are opposite, petiolate, glossy, mostly ovate, 15-35 cm long. Flowers white, up to 15 mm long, with a tubular corolla and 5 spreading lobes, the flowers borne on a globose syncarp. Fruit a large fleshy syncarp up...

In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive ...

BACKGROUND AND OBJECTIVES   The present study was conducted to investigate the possible gastroprotective effect of sildenafil citrate, a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, against indomethacin-induced gastric damage in rats. Further, the study was extended to investigate some possible mechanisms underlying this effect. MATERIALS AND METHODS Forty...

aqueous (hydrophilic) and chloroform (lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in egypt, to treat some gastrointestinal tract (git) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. indomethacin-induced ulcer in a rat model was used for this testing. mentha microphylla, brassica oleracea capitata (cabbage...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in Egypt, to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage...

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in Egypt, to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage...

Nitric oxide (NO) appears to play a critical role in modulating gastric mucosal defense. Administration of NO donors has been reported to protect the gastrointestinal mucosa against damage induced by several irritants. However, the possible role of NO in healing existing ulcers must be clarified further. Therefore, the present study was designed to assess the effect of modulation of NO on the h...

In search of novel gastroprotective agents, mangiferin, a naturally occurring glucosylxanthone from Mangifera indica L. (Anacardiaceae), was evaluated in mice on gastric injury induced by ethanol and indomethacin. The effects of mangiferin on gastric mucosal damage were assessed by determination of changes in mean gastric lesion area or ulcer score in mice and on gastric secretory volume and to...

BACKGROUND/AIMS To investigate the gastroprotective effects of grape seed proanthocyanidin extracts (GSPEs) against nonsteroid anti-inflammatory drug (NSAID)-induced gastric mucosal injury in rats. METHODS Sprague-Dawley rats were randomly allocated to the normal control, indomethacin, low-dose GSPE, high-dose GSPE and misoprostol groups. All groups except the normal control group received pr...