نتایج جستجو برای: gemifloxacin

تعداد نتایج: 277  

Journal: :The Journal of biological chemistry 2005
Elisabetta Leo Katherine A Gould Xiao-Su Pan Giovanni Capranico Mark R Sanderson Manlio Palumbo L Mark Fisher

Topoisomerase (topo) IV and gyrase are bacterial type IIA DNA topoisomerases essential for DNA replication and chromosome segregation that act via a transient double-stranded DNA break involving a covalent enzyme-DNA "cleavage complex." Despite their mechanistic importance, the DNA breakage determinants are not understood for any bacterial type II enzyme. We investigated DNA cleavage by Strepto...

Journal: :Antimicrobial agents and chemotherapy 2002
E Pérez-Trallero C García-Rey A M Martín-Sánchez L Aguilar J García-de-Lomas J Ruiz

Six quinolones were tested on 817 consecutive pneumococcal isolates for which ciprofloxacin MICs were high (> or =2 microg/ml); the isolates had been collected during two recent Spanish surveillance studies. For strains for which the ciprofloxacin MIC was >or =4 microg/ml, the MICs at which 90% of the isolates tested against gemifloxacin, moxifloxacin, gatifloxacin, sparfloxacin, levofloxacin, ...

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