Inst-Gen is an instantiation-based reasoning method for first-order logic introduced in [18]. One of the distinctive features of Inst-Gen is a modular combination of first-order reasoning with efficient ground reasoning. Thus, Inst-Gen provides a framework for utilising efficient off-the-shelf propositional SAT and SMT solvers as part of general first-order reasoning. In this paper we present a...

Both podocytes and glomerular endothelial cells (GEN) are postulated to play important roles in the progression and potential regression of glomerulosclerosis. Inhibition of angiotensin is crucial in treatment of chronic kidney disease, presumably via effects on BP and extracellular matrix. This study aimed to investigate how angiotensin inhibition altered the interactions between podocytes and...

PURPOSE The aim of this study was to evaluate the accuracy of ORange(®) Gen II (WaveTec Vision, Aliso Viejo, CA). SETTING The Surgical Suites, Honolulu, HI. METHODS The prospective 28 consecutive cataract surgical cases were selected from 85 cataract surgical cases between December 16, 2010 and February 24, 2011. With the same intraocular lens implantation, the predicted spherical equivalen...

We reviewed the species of genus Dolichostyrax Aurivillius (Cerambycidae: Morimopsini) from Borneo, which included the redescriptions of two species - Dolichostyrax moultoni Aurivillius, 1911 and Dolichostyrax longipes Aurivillius, 1913, with the first female description for the latter. After the examination of the additional material previously identified as Dolichostyrax, we described three n...

Early postnatal exposures to Bisphenol A (BPA) and genistein (GEN) have been reported to predispose for and against mammary cancer, respectively, in adult rats. Since the changes in cancer susceptibility occurs in the absence of the original chemical exposure, we have investigated the potential of epigenetics to account for these changes. DNA methylation studies reveal that prepubertal BPA expo...

Tissue-selective estrogen complex (TSEC), which combines a selective estrogen receptor modulator (SERM) with one or more estrogens, is a novel approach to menopausal therapy. It has been demonstrated that the phytoestrogen genistein (GEN) exhibits mixed estrogen receptor agonist and antagonist activity, suggesting that GEN may have potential for use as a natural SERM. We evaluated, for the firs...

Background: Previous studies have suggested a causative role for agonists of the aromatic hydrocarbon receptor (AhR) in the etiology of breast cancer 1, early-onset (BRCA-1)–silenced breast tumors, for which prospects for treatment remain poor. Objectives: We investigated the regulation of BRCA1 by the soy isoflavone genistein (GEN) in human estrogen receptor a (ERa)–positive Michigan Cancer Fo...

Gentamicin (GEN) is an aminoglycoside antibiotic with a potent antibacterial activity against a wide variety of bacteria. However, its poor cellular penetration limits its use in the treatment of infections caused by intracellular pathogens. One potential strategy to overcome this problem is the use of particulate carriers that can target the intracellular sites of infection. In this study GEN ...

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BACKGROUND AND OBJECTIVES The authors produced a historical analysis of nine anesthesia-related premises described in the Bible more than 3,500 years ago (Old Testament). Anesthetic drugs and adjuvants, patients, anesthesiologists attitudes and techniques are discussed in the light of Biblical and modern science. CONTENTS To help understanding, the nine premises evaluated are correlated to th...