Background: Salivary gland tumors (SGT) are rare lesions with uncertain histopathology. One of the major signaling pathways that participate in the development of several tumors is protein kinase A. In this pathway, glycogen synthase kinase β (GSK3β) and cAMP responsive element binding protein (CREB3) are two genes which are supposed to be down regulated in most human tumors. The expression lev...

Since 1845, when the term leukemia was used for the first time by Virchow, advances in biochemistry, cytogenetics, cytochemistry, immunology, and subsequently molecular biology have led to the identification of different subtypes of acute myeloid leukemia (AML). Especially during the last couple of years, the almost exponentially growing understanding of the hematopoietic system has revealed th...

• Simple workflow and analysis—the simplicity and speed of PCR enables a rapid method for gene expression profiling with a ≤2-day workflow from sample to analysis. Intuitive bioinformatics through point-andclick run setup and automated secondary data analysis in Torrent SuiteTM Software with an associated plug-in, the AmpliSeqRNA, enables unambiguous gene expression analysis and visualization f...

The gene expression array method enables us to achieve expression profiling with thousands of genes. Clinically resected bulk cancer tissues, however, contain not only cancer cells but also stromal cells, which may affect gene expression profiling and hamper accurate analysis of the cancer cells per se. Therefore, a procedure for dissecting specific cells, such as laser capture microdissection,...

The post-genomic era is characterized by a range of high throughput profiling methods capable broadly characterizing gene expression levels, protein, and metabolite abundances. Application these methods, enzyme profiling, more recently, protein-metabolite interactions flux analysis have alongside modeling approaches allowed us to refine our understanding the regulation metabolism even in case c...

background: apoptosis is a process that plays an important role during early stage of implantation. the aim of this study was to investigate the incidence of apoptosis in mice endometrium after ovarian stimulation at implantation period. methods: nmri female mice were divided into two groups: 1) control group, which were rendered pseudopregnant by vaginal stimulation and 2) experimental group, ...

schizophrenia (scz) is a complex disorder with no clarified etiology or biological diagnosis.  symptoms of schizophrenia including positive, negative and cognitive deficits.the neurodegenrative and neurodevelopmental hypothesis are main views  about the pathophysiology of schizophrenia. neuregulin 1 is one of four proteins in the neuregulin family that act on the egfr family of receptors. nrg1 ...

Abstract Gene regulatory variations accumulate during evolution and alter gene expression. While the importance of expression variation in phenotypic is well established, molecular basis remains largely unknown. Here, we examine two closely related yeast species, Saccharomyces cerevisiae paradoxus, which show phenotypical differences morphology cell cycle progression when grown same environment...

objective(s): streptococcus pyogenes produces extracellular hyaluronidase enzyme. this enzyme is directly associated with the spread of the organism during infection. the objective of the present study was to clone and express the nucleotide sequence of the enzyme which is involved in hyaluronidase enzymatic activity. materials and methods: the enzymatic region of hyaluronidase gene was detecte...