conclusions results from the present study elucidated that treatment with the aqueous extract of l. citriodora leaves was well tolerated via daily ip injection at doses up to 200 mg/kg for a period of 21 days and did not produce any toxicity. the safety of l. citriodora aqueous extract was also confirmed by cell viability assay. objectives the present study evaluated the acute, subacute, and ce...

OBJECTIVES The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity profiling of graphene family nananomaterials (GFNs) in alternative in vitro and in vivo toxicity testing models. METHODS The GFNs used in this study are graphene nanoplatelet...

antibiotic resistance to microorganisms is one of the major problems faced in the field of wound care in burns patients. silver nanoparticles have come up as potent antimicrobial agent and are being evaluated in diverse medical applications ranging from silver based dressings to silver coated medical devices. we aimed in present study to test the release of nanosilver from nanosilver wound dres...

BACKGROUND AND OBJECTIVES Gilbert's syndrome is a chronic benign disease leading to recurrent jaundice and major unconjugated bilirubin increase that may be toxic after the use of routine medication. This report aimed at describing the anesthetic approach in Gilbert's syndrome patient submitted to videolaparoscopic surgery. CASE REPORT Female patient, 22 years old with Gilbert's syndrome, sub...

Toxicity of phytochemicals, plant-based extracts and dietary supplements, and medicinal plants in general, is of medical importance and must be considered in phytotherapy and other plant uses. We show in this report how general database analyses can provide a quantitative assessment of research and evidence related to toxicity of medicinal plants or specific phytochemicals. As examples, several...

Abstract Objectives This study aimed to evaluate the predictive value of Cancer Aging Research Group (CARG) in Iranian patients as a representative Middle East North Africa (MENA) region population. Methods prospective longitudinal involved 65 years and older starting new cytotoxic chemotherapy regimen. We did general (including Karnofsky performance status, KPS) CARG-based assessments before c...

acetaminophen is an analgesic and antipyretic drug, which is widely used by public and poisoning with this drug, is common. one of the most important adverse effects of acetaminophen poisoning is centrilobullar necrosis in hepatic cells, which depends on activity of microsomal cytochrome p-450 (cyp) enzymes. the aim of this investigation was to find out the protective effect of nifedipine again...

Many important discoveries have been made in the field of nanotechnology last 40 years. Since then, nanoparticles became nearly ubiquitous. With their spreading use, safety concerns warranted extensive research nanotoxicity. This paper offers information about occurrence, transport, and behaviour metallic aquatic environment. It further summarizes details parameters that dictate toxicity discus...

Tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most destructive pests of tomato in many parts of the world including Iran. The toxicity of emamectin benzoate alone and combined with acetamiprid, eforia (thiamethoxam + lambda-cyhalotrin) and hexaflumuron was evaluated against 2nd instar larvae of Tuta absoluta (Meyrick) under 25 ± 1 °C, the relative humidity of ...

Toxicity tests of 95% ethanol extract of the root of Antidesma acidum were studied in male and female rats. The oral acute toxicity test at 5,000 mg/kg revealed that the ethanol extract did not produce toxic effects on signs, general behavious, mortality and gross appearance of internal organs of rats. Furthermore, the oral sub-acute toxicity test at the dose of 1,000 mg/kg/day displayed no sig...