OBJECTIVE To improve the transparency of clinical trial generalizability and to illustrate the method using Type 2 diabetes as an example. METHODS Our data included 1,761 diabetes clinical trials and the electronic health records (EHR) of 26,120 patients with Type 2 diabetes who visited Columbia University Medical Center of New-York Presbyterian Hospital. The two populations were compared usi...

This paper addresses a recent criticism of experimental economics, by Levitt and List [2007ab, 2008], that lab experimental findings may not generalize to field settings. We argue against the criticism in three ways. First, experimental economics seeks to establish a general theory linking economic factors, such as incentives, rules, and norms, to behavior. Hence, generalizability from the lab ...

BACKGROUND In the light of both the importance and large numbers of case series and cohort studies (observational studies) in orthopaedic literature, it is remarkable that there is currently no validated measurement tool to appraise their quality. A Delphi approach was used to develop a checklist for reporting quality, methodological quality and generalizability of case series and cohorts in to...

The purpose of this study was to determine the interrepetition and interoccasion generalizability of grip strength measurements in patients with the diagnosis of proximal extensor carpi radialis brevis tendinitis. Thirty-five consecutive patients (mean age = 44.5 +/- 8.6 years; mean duration of symptoms = 3.9 +/- 3.5 months) fulfilling the eligibility criteria participated in the study. Measure...

OBJECTIVES Assessments of health technologies increasingly include economic evaluations conducted alongside clinical trials. One particular concern with economic evaluations conducted alongside clinical trials is the generalizability of results from one setting to another. Much of the focus relating to this topic has been on the generalizability of results between countries. However, the charac...