n engl j med 355;14 www.nejm.org october 5, 2006 1500 large thrombus burden. Indeed, a recent study comparing clinical and procedural characteristics among hospitals, mostly regarding elective percutaneous coronary intervention, invariably reported a contrast volume of more than 200 ml.5 Finally, the difference in the primary end point and the other clinical end points between the two N-acetylc...

PURPOSE To evaluate the age-related change in contrast sensitivity seen in a middle-aged to elderly Japanese population. METHODS Contrast sensitivity and visual acuity were measured in subjects aged 40 to 79 years randomly recruited from a community in Aichi prefecture near Nagoya, Japan. Contrast sensitivity tests were performed using the Vistech contrast sensitivity test chart (VCTS 6500). ...

OBJECTIVES The aim of the study was to investigate the effects of age and/or surgical approach on perioperative wound complication following ovariohysterectomy (OHE). METHODS A retrospective search of perioperative monitoring records from a shelter desexing program was conducted to identify cats that underwent OHE between 1 June 2010 and 31 December 2012 inclusive. A wound complication was de...

BACKGROUND HIV/AIDS treatment programs are currently being mounted in many developing nations that include palliative care services. While measures of palliative care have been developed and validated for resource rich settings, very little work exists to support an understanding of measurement for Africa, Latin America or Asia. METHODS This study investigates the construct validity of measur...

Previously, Mantel, Bohidar, and Ciminera (Mantel-Haenszel analyses of litter-matched time-to-response data, with modifi cations for recovery of interlitter information. Cancer Res., 37: 3863-3868, 1977) described how the Mantel-Haenszel method could be applied to litter-matched time-to-tumor data. Each litter would be treated as a separate stratum but only for as long as there remained contras...

BACKGROUND Antibiotic-associated diarrhoea can be attributed in part to imbalances in intestinal microflora. Therefore, probiotic preparations are used to prevent this diarrhoea. However, although several trials have been conducted, no conclusive evidence has been found of the efficacy of different preparations, e.g. Lactobacillus spp. and Saccharomyces spp. AIM To conduct a meta-analysis of ...

BACKGROUND Corticosteroids are first-line drugs for the treatment of a variety of conditions in women of childbearing age. Information regarding human pregnancy outcome with corticosteroids is limited. METHODS We collected prospectively and followed up 184 women exposed to prednisone in pregnancy and 188 pregnant women who were counseled by Motherisk for nonteratogenic exposure. The primary o...

A standard approach to analyzing n binary matched pairs being usually represented in n 2× 2 tables is to apply a subject-specific model; for the simplest situation it is the so-called Rasch Model. An alternative population-averaged approach is to apply a marginal model to the single 2 × 2 table formed by n subjects. For the situation of having an additional stratification variable with K levels...