this study investigated the relative effects of deductive and inductive form-focused instruction (ffi) on the acquisition of 4 non-generic definite article uses(cultural, situational, structural, and textual) as assessed by explicit and implicit outcome measures. the tests utilized to assess efl learners' acquisition of definite article uses were timed and untimed grammaticality judgment tests....

Cefetamet pivoxil is an oral third generation cephalosporin class of antibiotic which mainly used in the treatment and management both upper lower community acquired respiratory tract infection. Many branded generic formulations are available tablet dosage forms market, hence quality control play important role pharmaceutical industry. In present research work attempt has been made to develop v...

The aim of present study was to compare the quality of atenolol tablets and examine the possibility of biowaiver study for approval of generic drugs without additional in vivo bioequivalence study. Atenolol, a cardio selective β-blocker, could be clearly classified into BCS Class III and may be evaluated under biowaiver conditions. Due to the importance of atenolol and availability of different...

OBJECTIVE The aim of this study was to evaluate the bioequivalence of two drug products, generic clopidogrel bisulfate 75 mg film-coated tablets versus the reference Plavix(®) clopidogrel bisulfate 75 mg film-coated tablets. METHODS Bioequivalence of tablets was tested by comparisons against the reference brand product in accordance with the requirements of the Declaration of Helsinki, the cu...

Self-injection of high-dose buprenorphine is responsible for well-described complications. In 2011, we have been alerted by unusual but serious cutaneous complication among injection buprenorphine users. A prospective data collection identified 30 cases of necrotic cutaneous lesions after injection of filtered buprenorphine solution, among which 25 cases occurred following injection of buprenor...

The objective of this study was to compare the disintegration times among Canadian-marketed brand (alendronate 70 mg, alendronate 70 mg plus vitamin D 5600 IU, and risedronate 35 mg) and generic (Novo-alendronate 70 mg and Apo-alendronate 70 mg) once-weekly dosed bisphosphonates. All disintegration tests were performed with a Vanderkamp Disintegration Tester. Disintegration was deemed to have o...

The governments of many countries strongly support the production and clinical use of generic medicinal products which are “copies” of patented drugs and can be marked at lower cost. At present time bioequivalence testing is regarded as a useful methodology to perform comparisons among different products containing the same active ingredient. This report presents the results of comparative bioe...

The interchangeability between a generic and the respective reference drug is based on the concept of therapeutic equivalence between them, usually provided by evidence of pharmaceutical equivalence, bioequivalence, Good Manufacturing Practices (GMP), and quality control. This study aimed to evaluate the pharmaceutical equivalence between four brands of 500 mg aspirin tablets (two generic, G, a...

Objective: The purpose of this randomized, crossover study was to compare the bioavailability of a generic and innovator formulation of gatifloxacin 400 mg tablets under fasting conditions. Methods: Seventeen blood samples per period were collected from 24 healthy, Arab male volunteers over 36 hours, plasma gatifloxacin concentrations were determined by HPLC assay, and pharmacokinetic parameter...

Concerns have been raised regarding the postmarketing quality of generic drugs. This study assessed the pharmacokinetic and pharmacodynamic equivalence of generic and brand atenolol tablets in 24 healthy male volunteers in a single-dose, open, randomized, two-period crossover study under fasting conditions. Blood samples were collected for 24 h post dosing and assayed for atenolol using HPLC. B...