نتایج جستجو برای: genes expression
تعداد نتایج: 1118179 فیلتر نتایج به سال:
Background: Celiac Disease (CD) is a T cell-mediated disorder. Recent studies suggest the role of chemokines CXCL10 and CXCL11 to promote the arrival of cells into inflamed tissues and in lymphocytic recruitment in active CD. The aim of this study was to investigate the new specific primer pairs for analysis of human CXCL10 and CXCL11 genes in blood samples of CD patients by Polymerase Chain Re...
Evaluation of ATG7 and LC3 Autophagy Genes Expression in Newly Diagnosed AML patients Background and aim: Autophagy, known as cell death type II, is a housekeeping pathway that currently has been worked on in matters of tumorigenesis and leukemogenesis. Therefore, in this study expression levels of ATG7 and LC3 as two key genes are targeted in AML patients. Material and method: This...
Background/Objective: Gliomas are the most common of the primary brain tumors and accounted for more than 40% of all central nervous system (CNS) tumors. Glioblastoma (GBM) remains one of the most fatal human malignancies because of its high angiogenic. Foretinib is an oral multikinase inhibitor that represented antitumor activity in clinical studies. AURKA and AURKB genes have been shown to b...
Background: Stem Cell differentiation is a process composed of vast variety of factors which are controlled by a network of certain mechanisms. This study aims to determine the possible role of DNA methylation, a potent regulator of VHL, ECAD and RUNX3 genes during Erythroid differentiation driven by miR-451. Materials and Methods: To determine the methylation status of promoters and the e...
Introduction: Breast cancer is one of the most prevalent malignancies among women. Patients whose suffering from this condition, as a result of the use of conventional therapies often have a poor response to treatment and the relapse among them is frequent. In this study, the effects of staphylococcal enterotoxin type B on BAK، FAS، BAX، TNF-a، BCL-2 و Survivin genes expression in human breast ...
Background: It is known that acetylation level of the nuclear histones in cloned embryos is lower compare to normally developed embryos. Histone deacetylas inhibitors (HDACi) with improvement of acetylation level in these embryos can affect embryo quality in pre-implantation stage and expression level of different genes especially developmental genes. Materials and Methods: In this research, SA...
objective: hypoxia-inducible factor (hif)-1 plays an essential role in the body’s response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses. increased levels of hif-1α are associated with increased proliferation and more aggressive breast tumor development. lactobacilli have...
Extended Abstract Introduction and Objective: Polyploidy is one of the main factors in plant adaptation that can increase secondary metabolites production in plants. Salvia officinalis L. is a perennial plant from the Lamiaceae family with a long history of use in the medicinal industry. Tanshinones are crucial active compounds biosynthesized in Salvia. This study was aimed to analyze the expr...
Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...
background: vhl (von hippel-lindau), runx-3 (runt-related transcription factor 3), e-cadherin (epithelial cadherin), p15 (ink4a, cyclin dependent kinase inhibitor), and p16 (ink4b) genes are essential in hematopoiesis. the aim of this study was to explore the correlation between gene expression and promoter methylation in cd34+ stem cells before and after differentiation to erythroid lineage. m...
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