A novel synthesis of the aggregation pheromone of the Colorado potato beetle, Leptinotarsa decemlineata, has been developed based on a Sharpless asymmetric epoxidation in combination with a chemoselective alcohol oxidation using catalytic [(neocuproine)PdOAc]2OTf2. Employing this approach, the pheromone was synthesized in 3 steps, 80% yield and 86% ee from geraniol.

A stereoselective total synthesis of the natural antibiotic (-)-8-O-methyltetrangomycin 1 is reported. The essential steps for this convergent synthesis are the transformation of a geraniol epoxide into a chiral octadiyne derivative, which was converted into a triyne. The cobalt-mediated [2+2+2] cycloaddition of the triyne led to a benz[a]anthracene system, which was oxidized with Ag(Py)(2)MnO(...

Geraniol, an abundantly available naturally occurring allylic alcohol, has been used as a starting material to prepare a series of 6-[alpha-(3'-aryl-3'-hydroxypropyl)vinyl]-1,2,4-trioxanes. Some of these novel trioxanes have shown very promising antimalarial activity against multi-drug resistant Plasmodium yoelii in mice by both intramuscular (im) and oral routes.

From the unsaponifiable fraction (63 g) of linseed oil (25 kg), two terpenic alcohols were isolated by alumina column, thin-layer, and gas-liquid chromatography. They were identified as phytol and geranyl geraniol (a precursor of bi- and tricyclic diterpenes) by infrared and nuclear magnetic resonance spectroscopy, ozonolysis, and mass spectrometry.

The work presented in this thesis emphasizes the importance of considering oxidative activation in the toxicity assessment of fragrance chemicals. Compounds without contact allergenic properties can be activated either via autoxidation in contact with air or via cutaneous metabolism to reactive products which can cause contact allergy. It is important to prevent sensitization as the immunologic...

Several laboratory, anecdotal and clinical studies have been performed using the patented derivatives of 1,2,4-Trioxolane during a period spanning over 20 years. Observations obtained demonstrate the uniqueness of this product. The product, when properly formulated can exhibit properties ranging from being a biological response modifier, antirheumatic, immunomodulator, anti-inflammatory, antivi...