Testicular teratomas result from anomalies in embryonic germ cell development. In the 129 family of inbred mouse strains, teratomas arise during the same developmental period that male germ cells normally enter G1/G0 mitotic arrest and female germ cells initiate meiosis (the mitotic:meiotic switch). Dysregulation of this switch associates with teratoma susceptibility and involves three germ cel...

background: cryptorchidism is a common malformation in neonates; surgery or medical treatments are applied during childhood. untreated cryptorchid testes are in the risk of intratubular germ cell neoplasia (igcn) and consequently invasive testicular tumors which could be shown by immunohistochemistry staining for placental like acid phosphatase (plap) marker. objective: we designed this study t...

Teratomas are tumors of germ cell derivation consist of tissues derived from all the three germ cell layers. They comprise the most common extragonadal germ cell tumors (EGCT) in childhood. EGCTs of head and neck region account for only 5% of all benign and malignant germ cell tumors and for 6% of all teratomas. Primitive neuroectodermal tumor (PNET) arising from germ cell tumor is a distinct e...

leydig stromal cell tumor is a rare ovarian tumor that belongs to the group of sex-cord stromal tumors. they produce testosterone leading to hyperandrogenism. we present a 41yr old woman with symptoms of virilization and a mass of right adenex via ultra sonography, and a rise of total and free serum testosterone. an ovarian source of androgen was suspected and a surgery performed. a diagnosis o...

INTRODUCTION Testicular tumors can be classified as seminomatous and non-seminomatous germ-cell tumor (NSGCT) types. Mixed germ cell tumors contain more than one germ cell component and are much more common than any of the pure histologic forms representing 32%-60% of all germ cell tumors. The composition of these tumors varies. Here we present a rare case of a mixed germ cell tumor composed of...

Patient. A 65-year-old man was admitted with a large primary retroperitoneal tumor and an increased beta-human chorionic gonadotropin (beta-HCG) serum level. A germ cell tumor was suspected; however, a computed tomography-guided biopsy failed to enable tumor classification. After two courses of chemotherapy, the beta-HCG serum level had returned to the normal level and a diagnostic laparotomy w...