B. pseudomallei and B. mallei can survive hostile conditions, becoming resilient to many antimicrobial agents, including antibiotics. In the paper by Rholl et al. (2011), the resistance to β-lactams, such as ceftazidime, was investigated. Genetic analysis of penA gene, encoding a putative twin arginine translocase (TAT)-secreted β-lactamase, demonstrated that PenA is secreted via the TAT system...