Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, amorphous state inherently unstable toward recrystallization. Coamorphous systems drug and small-molecule excipient or two complementary drugs often show an enhanced stability. Diabetes hypertension are frequently coexistent. In this paper study on coamorphization antidiabe...

BACKGROUND Although numerous clinical trials have evaluated the body weight change achieved using diabetes medications alone or in combinations, the composition of body weight change in these clinical trials has rarely been assessed. OBJECTIVE We aimed to evaluate the effects of gliclazide, metformin, and acarbose monotherapy on body composition, fat distribution, and other cardiometabolic ri...

OBJECTIVES The aim of this study was to determine the influence of non-ionisable excipients hydroxypropyl-β-cyclodextrin (HPβCD) and poloxamers 407 and 188 on the supersaturation and precipitation kinetics of ibuprofen, gliclazide, propranolol and atenolol induced through solution pH shifts using the CheqSol method. METHODS The drug's kinetic and intrinsic aqueous solubilities were measured i...

This study investigated the possible antidiabetic role and therapeutic crucial action of the saponin fractions of the ethanolic extract of areal parts of the medicinal plant Anabasis articulata compared to currently available antidiabetic drug gliclazide (diamicron) against diabetic complications induced tissue injury in rats. Fractionation of hydro alcoholic extract from the aerial parts of An...

Gliclazide (G) is an antidiabetic drug commonly used in type 2 diabetes. It has extrapancreatic hypoglycemic effects, which makes it a good candidate in type 1 diabetes (T1D). In previous studies, we have shown that a gliclazide-bile acid mixture exerted a hypoglycemic effect in a rat model of T1D. We have also shown that a gliclazide-deoxycholic acid (G-DCA) mixture resulted in better G permea...

CONTEXT Mutations in the Kir6.2 subunit (KCNJ11) of the ATP-sensitive potassium channel (KATP) underlie neonatal diabetes mellitus. In severe cases, Kir6.2 mutations underlie developmental delay, epilepsy, and neonatal diabetes (DEND). All Kir6.2 mutations examined decrease the ATP inhibition of KATP, which is predicted to suppress electrical activity in neurons (peripheral and central), muscle...

A 55-year-old man presented to the emergency department with a 1-day history of upper abdominal pain, haematemesis and malaena on a background of aortic valve replacement and three-vessel coronary artery bypass graft surgery. At the time of admission, his medications included warfarin (target international normalised ratio [INR], 2–3), metformin, gliclazide, ezetimibe, fenofibrate, carvedilol, ...