Millions of people cannot access essential medicines they need for deadly diseases like malaria, tuberculosis (TB) and HIV/AIDS. There is good information on the need for drugs for these diseases but until now, no global estimate of the impact drugs are having on this burden. This paper presents a model measuring companies' key malaria, TB and HIV/AIDS drugs' consequences for global health (glo...

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Background: It is assumed in polycystic ovary syndrome (PCOS) that follicular development, maturation, ovulation and implantation are impaired due to hormonal imbalance and vascular impairment of the ovarian and uterine vasculatures. The mechanism of action of laparoscopic ovarian drilling (LOD) is largely unexplained. To date, only limited studies have been conducted utilizing 3D ultrasonograp...

In this paper we explore the Khovanskii method for proving the finite cyclicity of elementary graphics and how it can be applied in practice. In particular we discuss some of the genericity conditions which allow to prove finite cyclicity for elementary graphics with the Khovanskii method. By comparing them with other known finite cyclicity theorems for elementary graphics we see that they form...

Research subject. Ostracods and Givetian-Frasnian boundary deposits of the Timan-North Urals Region. Materials methods. The work was based on results studying ostracods from stratotype sections Southern Timan, which are considered referential for regional global correlations. analysis distribution intervals most significant taxa previous studies, both published archival materials Timan-Urals we...

The current paper develops three different ways to measure the multi-period global cost efficiency for homogeneous networks of processes when the prices of exogenous inputs are known at all time periods. A multi-period network data envelopment analysis model is presented to measure the minimum cost of the network system based on the global production possibility set. We show that there is a rel...

in this study, estimation of global and diffuse solar radiations of selected cities in nigeria was carried out to assess the feasibility of solar energy utilization. the results of this work show the variation of direct and diffuse component of solar radiation in summer and winter months. the contribution of diffuse solar radiation is high during the monsoon months whereas sky conditions are cl...

OBJECTIVE Cyclical Cushing's syndrome may render the diagnosis and management of Cushing's disease difficult. The aim of the present study was to investigate the prevalence of cyclicity and variability in patients with Cushing's disease, and to identify putative distinctive features. DESIGN Retrospective case-note study. METHODS We analysed the case records of 201 patients with Cushing's di...

Multicomponent cyclicity in influenza (flu) incidence had been observed in various countries (e.g. periods T = 1, 2-3, 5-6, 8·0, 10·6-11·3, 13, 18-19 years) and its close similarity with cycles in natural environmental phenomena as meteorological factors and heliogeophysical activity (HGA) suggested. This report aimed at verifying previous results on cyclic patterns of flu incidence by explorin...

Adult female rats continuously exposed to androgens from prepuberty have reproductive and metabolic features of polycystic ovary syndrome (PCOS). We investigated whether such exposure adversely affects estrous cyclicity and the expression and distribution of gonadotropin-releasing hormone (GnRH), GnRH receptors, and corticotrophin-releasing hormone (CRH) in the hypothalamus and whether the effe...