D iscussion about gestational diabetes mellitus (GDM) is slowly creating traction on the best way forward. Recent evidence has confirmed that there is a continuum of risk for adverse maternal and fetal outcomes as the maternal glucose level rises (1,2). There is an increasing number of studies supporting the importance of fuel-mediated teratogenesis, including epigenetic influences, that are le...

OBJECTIVE The purpose of this study was to determine how the range of measured maternal glycemia in pregnancy relates to risk of obesity in childhood. RESEARCH DESIGN AND METHODS Universal gestational diabetes mellitus (GDM) screening (a 50-g glucose challenge test [GCT]) was performed in two regions (Northwest and Hawaii) of a large diverse HMO during 1995-2000, and GDM was diagnosed/treated...

M e t h o d s Design: Randomized controlled trial (Australian Carbohydrate Intolerance Study in Pregnant Women [ACHOIS]). Allocation: {Concealed}†.* Blinding: Blinded {outcome assessors, data analysts, and data safety and monitoring committee; outcome assessors for shoulder dystocia were not blinded}†.* Follow-up period: Birth to hospital discharge. Setting: 16 hospitals in Australia. Patients:...

Adipokine dysregulation and subclinical inflammation are putative diabetogenic features of adiposity. However, while alterations in adipokines/inflammatory proteins can predict incident type 2 diabetes in longitudinal studies (1–3), evidence for causality is generally hindered by two limitations. First, there is a relative paucity of human data linking changes in adipokines/inflammatory protein...

OBJECTIVE To examine the hypothesis that early second trimester amniotic fluid (AF) insulin concentration is elevated and later fetal growth is augmented in gravidas demonstrating later oral glucose intolerance. RESEARCH DESIGN AND METHODS In this prospective observational cohort study, AF was sampled at 14-20 weeks' gestation in 247 subjects, and 1-h 50-g oral glucose challenge tests (GCTs) ...

BACKGROUND There is lack of consensus concerning the best screening strategy for gestational diabetes (GDM). The aim of our survey was therefore to investigate attitudes and practices of all obstetrical centers in the northern part of Belgium regarding screening for pregestational diabetes in early pregnancy and screening for GDM. We also aimed to identify the penetrance of the 'International A...

BACKGROUND The objective of this study was to investigate the associations among the mid-pregnancy glycated hemoglobin A1c (HbA1c) level, gestational diabetes (GDM), and risk of adverse pregnancy outcomes in women without overt diabetes and with positive 50-g, 1-h glucose challenge test (GCT) results (140 mg/dL or greater). METHODS This prospective study enrolled 1,989 pregnant Taiwanese wome...

Objective: To determine the frequency of gestational diabetes mellitus (GDM) among pregnant females. Study Design: Cross-sectional study. Place and Duration: Department Gynecology Obstetrics, department Pathology, Dow University health sciences, From February 2021 to January 2022. Methodology: Five hundred ladies with age between 24-28 weeks any parity were included. These women challenged 75 g...

The purpose of this study was to assess the reproducibility (test-retest reliability and agreement) and concurrent validity of the Myotest for measuring step frequency (SF) and ground contact time (GCT) in recreational runners. Based on a within-subjects design (test and retest), SF and GCT of 14 participants (11 males, 3 females) were measured at three different running speeds with the Myotest...