GHSr signaling is involved in the regulation of energy homeostasis. LEAP2, a recentlydiscovered peptide hormone, counteracts effects ghrelin. This study sought to evaluatethe perinatal LEAP2 exposure young rat offspring. For this, two protocols weredesigned assess roles antagonism during pregnancy and thelactation. Sex-specific impacts on AUC peak-responses glucose tolerance tests werepresented...

OBJECTIVE The induction of hepatic glucose 6-phosphatase (G6pc) by glucose presents a paradox of glucose-induced glucose intolerance. We tested whether glucose regulation of liver gene expression is geared toward intracellular homeostasis. RESEARCH DESIGN AND METHODS The effect of glucose-induced accumulation of phosphorylated intermediates on expression of glucokinase (Gck) and its regulator...