Muscle fiber is the basic unit of skeletal muscle. types play a crucial role in improving meat quality. In current study, Wistar rats were chronic injected with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) for four weeks order to define 5′-AMP-activated protein kinase (AMPK) activity on muscle composition, enzyme and mRNA expression type-related genes gastrocnemius (GS) Food inta...

OBJECTIVE Remogliflozin etabonate (RE), an inhibitor of the sodium-glucose transporter 2, improves glucose profiles in type 2 diabetes. This study assessed safety, tolerability, pharmacokinetics, and pharmacodynamics of RE in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS Ten subjects managed with continuous subcutaneous insulin infusion were enrolled. In addition to basal insulin...

To clarify the function of the Na(+)-coupled glucose transporter in the regulation of cellular tone of cultured retinal pericytes, we investigated the effects of extracellular glucose concentration on cell size. The surface area and diameter of cultured bovine retinal pericytes under different glucose concentrations were measured by using a light microscope with a digital camera. We also examin...

The transport of glucose across the plasma membrane is mediated by members of the glucose transporter family. In this study, we investigated glucose uptake through the yeast hexose transporter 1 (Hxt1) by measuring incorporation of 2-NBDG, a non-metabolizable, fluorescent glucose analog, into the yeast Saccharomyces cerevisiae. We find that 2-NBDG is not incorporated into the hxt null strain la...

One of the leading causes diabetes-related deaths is myocardial damage, which may be cause heart failure in people with type 2 diabetes mellitus. The objective research was to look at impact coronary kind a pair This project aimed explore protective oleanolic acid on damage mellitus and investigate connected mechanism. Specific pathogen free grade db/db male mice were elected as model, while Db...

The beneficial effects of exercise on type 2 diabetics have been welldocumented, including restoration of glycemic control [1-3]. At the molecular level, an increase in the translocation of glucose transporter 4 (GLUT-4) following the activation of phosphatidylinositol 3-kinase (PI3-kinase), and protein kinases B (Akt) and C ζ/λ (PKCζ/λ) improves glycemic control [4,5]. Thus, chronic exercise p...

We measured net fetal glucose uptake rate from the placenta, shown previously to be equal to total fetal glucose utilization rate (GUR(f)) and proportional to fetal hindlimb skeletal muscle glucose utilization, under normal conditions and after 1, 2.5, and 24 h of selective hyperglycemia increasing G or selective hyperinsulinemia increasing I. We simultaneously measured the amount of Glut 1 and...

Objective(s): The aim of this study was to explore the molecular mechanism of mirtazapine with respect to energy metabolism in Streptozotocin-induced diabetic liver of rats by immunohistochemistry and Western blot. Materials and Methods: Twenty-one male Sprague-Dawley rats were assigned into 3 groups including control, type 1 diabetes me...

This study investigated the blood glucose-lowering effect and antioxidant capacity of caffeic acid in C57BL/KsJ-db/db mice. Caffeic acid induced a significant reduction of the blood glucose and glycosylated hemoglobin levels than the control group. The plasma insulin, C-peptide, and leptin levels in caffeic acid group were significantly higher than those of the control group, whereas the plasma...