Nephrotoxicity of chemotherapeutics is a major hindrance in the treatment of various tumors. Therefore, test systems that reflect mechanisms of human kidney toxicity are necessary, and to reduce animal testing cell culture based systems have to be developed. One cell type that is of specific interest in this regard are renal proximal tubular epithelial cells, as they reabsorb substances from hu...

this prospective study aimed to compare the intraosseous (io) and intravenous (iv) effects of propofol on selected blood parameters and physiological variables during general anesthesia in rabbits. thirty new zealand white rabbits were studied. six rabbits received iv propofol (group 1) and another 6 rabbits, were injected propofol intraosseously (group 2) for 30 minutes (experimental groups). ...

OBJECTIVES To determine the effect of a modified request form on the total use of γ-glutamyl transferase (GGT) usage and the ratio of inappropriate testing. METHODS We modified a test request form by moving GGT from the "Liver profile" to the "Other" section. The criteria for appropriate GGT ordering were developed based on literature review and then validated by expert consensus. To determin...

Jean, Jyh Chang, Yue Liu, Lou Ann Brown, Robert E. Marc, Elizabeth Klings, and Martin Joyce-Brady. -Glutamyl transferase deficiency results in lung oxidant stress in normoxia. Am J Physiol Lung Cell Mol Physiol 283: L766–L776, 2002. First published May 3, 2002; 10.1152/ ajplung.00250.2000.— -Glutamyl transferase (GGT) is critical to glutathione homeostasis by providing substrates for glutathion...

Background: Atrial fibrillation (AF) is the most commonly diagnosed cardiac arrhythmia in clinical practice and is related to significant morbidity and mortality. AF etiology and thus, predictive biomarkers are currently lacking. Liver enzymes have shown a correlation to cardiovascular disease. Gamma-glutamyl transferase (GGT) is a liver enzyme associated with oxidative stress that is postulate...

BACKGROUND The serum level of gamma glutaryl transferase and alkaline phosphatase is raised in acute calculus cholecystitis and common bile duct stone. However, the rise in serum level of these enzymes in acute cholecystitis implies stone in the common bile duct is not well studied. Thus, it may lead to retained CBD stone on one side and unnecessary CBD exploration on the other during emergency...

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into fou...

Accumulating evidence from epidemiological studies suggests that higher γ-glutamyl transferase (GGT) levels in the blood are associated with the incident of cardiovascular disease (CVD), including atherosclerosis, and have prognostic importance. However, to the best of our knowledge, the association of the GGT level with premature coronary artery disease (CAD) in an Asian Indian population has ...

Gamma-glutamyl transferase (GGT) is a second-generation enzymatic liver function test available for several decades, initially used as a sensitive indicator of alcohol ingestion, hepatic inflammation, fatty liver disease, and hepatitis. Longitudinal and cross-sectional investigational studies since 1990 have associated GGT with an increase in all-cause mortality, as well as chronic heart diseas...

Serum biochemical parameters can be utilized to evaluate the physiological status of an animal, and relate it to the animal's health. In order to accurately interpret individual animal biochemical results, species-specific reference intervals (RI) must be established. Reference intervals for biochemical parameters differ between species, and physiological differences including reproductive stat...