Coronary haemodynamic and metabolic effects of propranolol and glyceryl trinitrate were studied in 12 patients with coronary artery disease and 5 without coronary heart disease, at rest and during tachycardia stress. Propranolol-associated reductions in indices of myocardial oxygen demand, left ventricle work, tension time, and left ventricle oxygen utilisation (LVVO2) were reversed when heart ...

Prolipoprotein signal peptidase, a unique endopeptidase which recognizes glycyl glyceride cysteine as a cleavage site, was characterized in an in vitro assay system using purified prolipoprotein as the substrate. This enzyme did not require phospholipids for its catalytic activity and was found to be localized in the inner cytoplasmic membrane of the Escherichia coli cell envelope. Globomycin i...

BACKGROUND AND AIMS The main aims of the present study were to formulate an anti-age cream based on vegetal ingredients and ferulic acid and to evaluate the physical characteristics and the efficacy of the cream. METHODS The active ingredients were Centella asiatica oil, Spilanthes acmella oil, Zingiber officinale extract and ferulic acid. Formulation 1 (F1) was prepared using glyceryl steara...

Aerosolization is a non-invasive approach in drug delivery for localized and systemic effect. Nanostructured lipid carriers (NLCs) are new generation versatile carriers, which offer protection from degradation enhance bioavailability of poorly water soluble drugs. The aim this study was to develop optimize NLC formulations combination with optimized airflow rates (i.e. 60 15 L/min) choice medic...

The aim of this study was to synthesize by high shear homogenization method and to characterize new solid lipid nanoparticles loaded with green tea extract, nanoparticles which show high antioxidant activity. In this respect, cetyl palmitate and glyceryl stearate were used as solid lipids in combination with two nonionic surfactants, Tween20 and Tween80 and an ionic surfactant as lecithin. The ...

An enzyme present in the microsomes of small intestinal mucosa cells was partially purified by a combination of several conventional methods: solubilization with deoxycholate, (NH&SO4 fractionation, diethylaminoethyl Sephadex column chromatography, carboxymethyl Sephadex treatment, and finally starch zone electrophoresis. The purified enzyme preparation had a specific activity 300 times that of...

Because of the high efficacy of existing nitrates, alternative dosage formulations have been developed rather than new compounds. These new formulations challenge the analyst to develop analytical methods with lower sensitivity and higher precision. Isosorbide dinitrate is analysed in the presence of its major metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate. The present method...

Objectives: To find out the effect of topical glyceryl trinitrate on the symptoms and signs of acute anal fissure. Patients And Methods: Seventy-five patients were treated with 0.2% topical glyceryl trinitrate twice daily as local application in the anal canal with the help of cotton pledget, which was soaked in the ointment for four weeks and their symptomatology, and healing of anal fissure w...

Application of a small dose of glyceryl trinitrate paste (0.25 in) resulted in severe left ventricular dysfunction with the appearance of pulsus alternans in a patient with alcoholic cardiomyopathy. The echocardiogram showed a reduction in the amplitude and velocity of motion of the left ventricular posterior wall on alternate beats. Leg elevation promptly reversed the pulsus alternans, and the...