Cancers of diverse origins exhibit marked glucose avidity and high rates of aerobic glycolysis. Increased understanding of this dysfunctional metabolism known as the Warburg effect has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting is glycoconjugation, the linking of a drug to glucose or another sugar. This review summarizes the most salient exa...

Lipophosphoglycan is a prominent member of the phosphoglycan-containing surface glycoconjugates of Leishmania. Genetic tests enable confirmation of its role in parasite virulence and permit discrimination between the roles of lipophosphoglycan and related glycoconjugates. When two different lipophosphoglycan biosynthetic genes from Leishmania major were knocked out, there was a clear loss of vi...

CONTENTS I N T R O D U C T I O N . COLONIZATION O F THE INTESTINAL TRACT . . T H E GLYCOCONJUGATE CHEMISTRY O F INTESTINAL S U R F A C E S MEMBRANE GLYCOCONJUGATES . . M U C I N GLYCOCONJUGATES . BACTERIAL A D H E S I N S A N D INTESTINAL RECEPTORS . . FIMBRIAL ADHESINS . Type-I fimbriae . Fimbrial serotypes associated with diarrhoea1 disease . Fimbrial adhesins associated with Helicobacter pyl...

In the abomasal epithelium of the goat, glycoconjugates have been studied by means of selective histochemical methods. The staining procedures employed were alcian blue (AB) pH 1.0 AB pH 2.5, Periodic acid Schiff (PAS) and AB pH 2.5-PAS. In addition twelve lectins, Triticum vulgaris WGA, Concana valin A, Glycine max SBA, Dolichos biflorus DBA, Arachis hypogea PNA, Solanum tuberosum STL, Datura ...

Seven types of ferritinized lectin were used to examine the distribution of glycoconjugates on the outer segment membranes of lamprey photoreceptor cells. Ultrastructural pre-embedding labeling revealed that peanut agglutinin, soybean agglutinin and Ricinus communis agglutinin I were preferentially bound to the proximal, lateral and luminal surfaces of the long cell outer segments, whereas Grif...

Molecular weights (molar masses), molecular weight distributions, dissociation constants and other interaction parameters are fundamental characteristics of proteins, nucleic acids, polysaccharides and glycoconjugates in solution. Sedimentation equilibrium analytical ultracentrifugation provides a powerful method with no supplementary immobilization, columns or membranes required. It is a parti...

Sections of normal ovarian surface epithelium, benign serous cystadenomas, borderline serous cystadenomas and serous cyst-adenocarcinomas were stained with a pattern of lectins (Con A, WGA, SBA, DBA, UEA I, PNA and RCA I) to determine the different glycoproteins and their cellular changes. The epithelial cells stained with Con A, WGA, UEA I and RCA, although the intensity of the staining was ge...

The interface between a mammalian host organism and the microflora in its intestinal lumen is the mucous gel layer and the underlying cell coat, or glycocalyx, of glycoconjugates on the apical surface of the epithelium. Oligosaccharides within this interface can serve as receptors for the attachment of microorganisms. The first challenge to would-be luminal pathogens is successful attachment to...