The interfacial characteristics between bioactive glass (45S5 Bioglass) surfaces and poly(α-hydroxyacid) melts have been assessed by direct wetting measurements. In particular, the wettability of Bioglass powder by poly(D,Llactide) (PDLLA) and poly(D,L-lactide-co-glycolide) (PLGA) was assessed by imbibition measurements. Additionally, the equilibrium contact angles of PDLLA and PLGA melts on a ...

BACKGROUND Because of the described hazards related to inhalation of manufactured nanoparticles, we investigated the lung toxicity of biodegradable poly (lactide-co-glycolide) (PLGA) nanoparticles displaying various surface properties on human bronchial Calu-3 cells. METHODS Positively and negatively charged as well as neutral nanoparticles were tailored by coating their surface with chitosan...

Organic molecules that are active in the near-infrared (NIR) bio-window for photo-to-heat energy-converting theranostics have attracted much attention cancer therapy. However, current organic NIR-absorbing still suffering from inefficient non-radiative decay or serious photobleaching under light irradiation. Herein, we design a convenient strategy to load new kind of nonlinear optical (NLO) chr...

The purpose of this study was to develop freeze dried Polylactide-co-glycolide (PLGA) nanoparticles loaded with etoposide intended be administered intravenously improved therapeutic efficacy the drug and thereby reduced dose related toxicity associated it. were prepared using modified spontaneous emulsification solvent diffusion method (SESD).The in Vitro release (PLGA)–Nanoparticles NP carried...

Gene delivery holds therapeutic promise for the treatment of neurological diseases and spinal cord injury. Although several studies have investigated the use of non-viral vectors, such as polyethylenimine (PEI), their clinical value is limited by their cytotoxicity. Recently, biodegradable poly (lactide-co-glycolide) (PLGA) nanospheres have been explored as non-viral vectors. Here, we show that...

Objective: The objective of this study is to fabricate favipiravir-loaded PLGA nanoparticulate systems that can increase the solubility along with sustained release favipiravir. Methods: Poly (D, L-lactic-co-glycolide) (PLGA) were prepared by nanoprecipitation method. A 3-factor, 2-level central composite face-centered design was employed effect formulation variables having a concentration PLGA...

Strategies that target and treat biofilms are widely applied to bacterial cultures using popular live/dead staining techniques with mostly red or green fluorescent markers (eg, with SYTO(®) 9, propidium iodide, fluorescein). Therefore, visualizing drugs or micro- and nanoparticulate delivery systems to analyze their distribution and effects in biofilms requires a third fluorescent dye that does...

BACKGROUND Nanomaterials have unique advantages in controlling stem cell function due to their biomimetic characteristics and special biological and mechanical properties. Controlling adhesion and differentiation of stem cells is critical for tissue regeneration. METHODS This in vitro study investigated the effects of nano-hydroxyapatite, nano-hydroxyapatite-polylactide- co-glycolide (PLGA) c...

The development of tissue engineering in the field of orthopedic surgery is booming. Two fields of research in particular have emerged: approaches for tailoring the surface properties of implantable materials with osteoinductive factors as well as evaluation of the response of osteogenic cells to these fabricated implanted materials (hybrid material). In the present study, we chemically grafted...

BACKGROUND This study was performed to develop a functional poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG)-bearing amino-active end group for peptide conjugation. METHODS AND RESULTS PLGA was preactivated following by copolymerization with PEG diamine. The resulting amphiphilic PLGA-PEG copolymer bearing 97.0% of amino end groups had a critical micelle concentration of 3.0 × ...