نتایج جستجو برای: gonadotropin

تعداد نتایج: 18109  

2015
Sun-Jeong Shin Ja Hye Kim Ja Hyang Cho Jae Hyun Kim Gu-Hwan Kim Jin-Ho Choi Han-Wook Yoo

Aims Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by delayed or absent sexual development associated with low gonadotropin and sex steroid levels. IGD is classified as Kallmann syndrome (KS) with anosmia and normosmic idiopathic hypogonadotropic hypogonadism (nIHH). This study was undertaken to investigate clinical and endocrinological profiles in patients wi...

Journal: :Journal of experimental zoology. Part A, Comparative experimental biology 2006
George E Bentley Lance J Kriegsfeld Tomohiro Osugi Kazuyoshi Ukena Sara O'Brien Nicole Perfito Ignacio T Moore Kazuyoshi Tsutsui John C Wingfield

Gonadotropin-releasing hormone (GnRH) regulates secretion of both of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone. Thus, it is a key hormone for vertebrate reproduction. GnRH was considered to be unusual among hypothalamic neuropeptides in that it appeared to have no direct antagonist, although some neurochemicals and peripheral hormones (opiates, GABA, gonadal s...

Journal: :Japanese journal of clinical oncology 2013
Satoshi Nitta Koji Kawai Mizuki Onozawa Satoshi Ando Jun Miyazaki Chigusa Nagata Masayuki Noguchi Kazumitsu Yamasaki Katsunori Uchida Teruaki Iwamoto Hiroyuki Nishiyama

We report the case of a 22-year-old male who had a history of metastatic right testicular tumor successfully treated with chemotherapy and surgery. Twenty-one months after the initial treatment, the serum human chorionic gonadotropin started to increase gradually, but whole body imaging including the left testis revealed no abnormal finding except testicular microlithiasis. A biopsy of the left...

Journal: :The Journal of biological chemistry 1986
R C Milton P J Wormald W Brandt R P Millar

The human gonadotropin-releasing hormone (GnRH) precursor consists of the GnRH sequence followed by a 59-amino acid carboxyl-terminal extension. A 56-amino acid peptide within this extension has been shown to stimulate gonadotropin release, and this activity has been localized to its amino-terminal region. A series of seven overlapping peptide fragments corresponding to the first 24 amino acids...

Journal: :The Journal of clinical investigation 1980
S B Cigorraga S Sorrell J Bator K J Catt M L Dufau

Leydig cells isolated from the testes of rats treated with intravenous exogenous gonadotropin (hCG) or subcutaneous gonadotropin-releasing hormone (GnRH) show markedly decreased luteinizing hormone (LH) receptors and a partial block in testicular 17,20 desmolase activity. In contrast, Leydig cells from animals with equivalent degrees of LH receptor loss induced by subcutaneous hCG treatment sho...

Journal: :Frontiers in endocrinology 2016
Ishwar S. Parhar Satoshi Ogawa Takayoshi Ubuka

Social behaviors are key components of reproduction, because they are essential for successful fertilization. Social behaviors, such as courtship, mating, and aggression, are strongly associated with sex steroids, such as testosterone, estradiol, and progesterone. Secretion of sex steroids from the gonads is regulated by the hypothalamus-pituitary-gonadal (HPG) axis in vertebrates. Gonadotropin...

2017
Anat Hershko Klement Adrian Shulman

Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnanc...

Journal: :The Journal of biological chemistry 1974
F Haour B B Saxena

Plasma membranes isolated from bovine corpora lutea showed specific binding with 1251-human chorionic gonadotropin and 1251-human luteinizing hormone; unlabeled hormones competitively inhibited the binding. The binding of the 1251-human chorionic gonadotropin to the receptor was a saturable phenomenon and the half-saturation was attained at a concentration of 4 X lo-r0 M. Maximum hormone recept...

Journal: :The Journal of biological chemistry 1991
S L Young R P Searles A H Kaynard M H Melner

Gonadotropins (follicle-stimulating hormone (FSH), luteinizing hormone, and human chorionic gonadotropin) and beta-adrenergic agonists have been shown to stimulate expression of the proopiomelanocortin (POMC) gene in ovarian granulosa cells. The current studies investigate the intracellular mechanisms by which gonadotropins regulate gene expression. Primary cultures of rat granulosa cells were ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1975
M L Dufau E J Podesta K J Catt

The physical properties of detergent-solubilized gonadotropin receptor-hormone complexes, determined by density gradient centrifugation and gel filtration, were compared after in vivo and in vitro labeling of specific ovarian binding sites with radioiodinated human chorionic gonadotropin (hCG). Following intravenous administration of biologically active 125I-labeled hCG, up to 50% of the gonado...

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