BACKGROUND For the last year we have been treating normal responders with gonadotropins and letrozole during the whole stimulation in order to improve response to FSH by increasing the intrafollicular androgen concentration, and to reduce circulating estrogen concentrations. The aim of this study was to compare the IVF outcome of normal responders treated with letrozole and gonadotropins during...

Synthesis and secretion of gonadotropic hormones is a complex process that requires precise regulation of genes encoding for the gonadompin-releasing hormone (GnRH) receptor, the common a-subunit of glycoprotein hormones and the individual P-subunits of the gonadotropins. These genes apparently can be influenced by gonadal steroids, GnRH and other peptide hormones such as activin and inhibin. G...

OBJECTIVE To compare timed intercourse and IUI with the husband's sperm in patients with unexplained infertility who are undergoing superovulation with gonadotropins. DESIGN Meta-analysis. All published reports of randomized, prospective studies with an English-language abstract extracted from MEDLINE were analyzed. A crossover search was done from the papers obtained. SETTING Academic cent...

BACKGROUND Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to analyze gonadotropins levels in girls with TS throughout childhood. METHODS Retrospective longitudinal study conducted with 15 girls with TS diagnosed with < 5 years whose FSH a...

This Technical Bulletin reviews the indications for gonadotropin treatment in anovulatory women; outlines the recommended pretreatment evaluation, treatment regimens, and monitoring; describes the alternatives and adjuncts to treatment with gonadotropins; and summarizes the complications of gonadotropin treatment.

Background: Despite the large number of papers published on the efficiency of different exogenous gonadotropins, no confirmed protocol exists. Therefore, the aim of the present study was to compare the efficacy of 4 exogenous gonadotropins in IVF/ICSI cycles.Methods: This study, performed from January 2014 to May 2014, recruited 160 women referred to Ghadir Mother and Child Hospital and Dena Ho...

A large body of evidence supports the protective role flavonol antioxidant compound quercetin in mammals. We tested hypothesis that can protect against hypothalamus-pituitary-gonadal (HPG) axis defect like a reduction gonadotropins and testicular hormones abnormal semen analysis induced by chronic unpredictable stress (CUS), possibly via downregulation oxidative (ROS) p53-Bax-caspase-3 pathways...