Introduction. Gorlin-Goltz syndrome is an inherited autosomal dominant disorder with complete penetrance and extreme variable expressivity. Case Report. The present paper highlights the importance of diagnostic criteria and histopathology in early and prompt diagnosis which will lead to proper treatment and genetic counseling of the patient. Discussion. Gorlin-Goltz syndrome is about multisyste...

In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins. Despite extant homology between certain subunits, the degree of structural and organizational overlap between budding yeast and metazoan ORC has been unclear. Using 3D electron microscopy, we determined the subunit organization of metazoa...

Gorlin-Goltz syndrome is an infrequent multi-systemic disease which is characterized by multiple keratocysts in the jaws, calcification of falx cerebri, and basal cell carcinomas. We report a case of Gorlin-Goltz syndrome in a 23-year-old man with emphasis on image findings of keratocyctic odontogenic tumors (KCOTs) on panoramic radiograph, computed tomography, magnetic resonance (MR) imaging, ...

Although odontogenic keratocysts are common in clinical practice, the simultaneous occurrence of multiple cysts in both the maxilla and mandible of a patient is rare. Gorlin-Goltz syndrome is an inherited autosomal dominant disorder with complete penetrance and extreme variable expressivity. It is characterized by keratocystic odontogenic tumors (KCOT) in the jaws, multiple basal cell nevi carc...

SINCE the introduction of the formula by Gorlin and Gorlin in 1951,1 the cardiologist has been able to predict cardiac valve areas with considerable accuracy. Although the formula has distinct limitations, particularly in the presence of valvular regurgitation, its application in determining the severity of valvular and outflow tract stenosis has been widely accepted. The mathematics of the for...

ACTA DERMATOVENEROLOGICA CROATICA The Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma (BCC), has a variable prevalence, estimated from 1/57,000 to 1:256,000 inhabitants (1). It is a rare autosomal dominant disorder due to a genetic mutation in the PTCH tumor suppressor gene localized to 9q22.3 chromosome (2). In order to make a diagnosis of Gorlin-Goltz syndrome, some diagnosti...