This study aimed to evaluate the effect of a sublethal dose of gossypol (20 mg/kg BW, every other day) on sperm malformed ultrastructure of male rabbits. The experiment lasted 8 weeks. Gossypol administration exhibited: severe deteriorations in the head, connecting piece and midpiece of the sperm; significant increases in the malformed acrosomes; dramatic destructions expressed as degeneration ...

We identify a cytochrome P450 gene (CYP6AE14) from cotton bollworm (Helicoverpa armigera), which permits this herbivore to tolerate otherwise inhibitory concentrations of the cotton metabolite, gossypol. CYP6AE14 is highly expressed in the midgut and its expression correlates with larval growth when gossypol is included in the diet. When larvae are fed plant material expressing double-stranded ...

infertility is a relatively common problem among couples, and gossypol, a yellowishpigment detected in cottonseed, is one cause.adult nmri mice (25-35 gr) were used in this study. the animals were kept in standard conditionswith a dark and light cycle of 12:12, controlled humidity and temperature, food and water were availableadlibitium.gossypol was dissolved in ethanol and diluted by sunflower...

We identify a cytochrome P450 gene (CYP6AE14) from cotton bollworm (Helicoverpa armigera), which permits this herbivore to tolerate otherwise inhibitory concentrations of the cotton metabolite, gossypol. CYP6AE14 is highly expressed in the midgut and its expression correlates with larval growth when gossypol is included in the diet. When larvae are fed plant material expressing double-stranded ...

Cottonseed is potential candidate to act as an important protein source but presence of toxic compound gossypol with concentration more than 0.045% main hurdle in utilization this protein. Optimized lyophilized powder constitutes 5.05% moisture, 93.1% crude protein, 0.03% free gossypol, 0.27% total and bacterial count 1295 cfu/g no pathogenic bacteria. may be utilized ingredient for food indust...

Cottonseed is an economical source of protein and is commonly used in balancing livestock rations; however, its use is typically limited by protein level, fat content, gossypol, and the potential for aflatoxin. Cottonseed and mixtures of cottonseed and cotton gin by-products (CGBP) were extruded at relatively high temperatures to determine if the process would reduce the free-gossypol and aflat...

The male contraceptive agent gossypol was found to induce a dose related increase of DNA strand breaks in human fibroblasts in vitro at concentrations of 5 to 40 micrograms/ml. The effect was reduced in the presence of 2% fetal calf serum. A weak but reproducible increase in the SCE frequency was found in human lymphocytes treated for 1 hour in serum-free medium with 0.04 to 4 micrograms/ml of ...

Abstract Background Gossypium hirsutum L. ( cotton) is one of the most economically important crops in world due to its significant source fiber, feed, foodstuff, oil and biofuel products. However, utilization cottonseed was limited presence small darkly pigmented glands that contain large amounts gossypol, which toxic human beings non-ruminant animals. To date, some progress has been made pigm...

The present study was designed to investigate the effect of a proteinaceous dietary supplement, fishmeal, on gossypol-induced spermatotoxicity. Twenty-five adult male Wistar rats, averaging 205 g b.w., were randomly sorted into four experimental groups (I-IV) of 5 animals each, and a control group. Crude cottonseed oil was administered orally to each animal in groups I-IV at a rate that provide...

An experiment was conducted to determine the effects of long-term feeding of cottonseed meal on the reproductive traits of Holstein bulls. Holstein bulls approximately 6 mo of age were placed on the following treatments: 1) soybean meal + corn (CON); 2) cottonseed meal + corn (GOS); and 3) cottonseed meal + 4,000 IU vitamin E x bull(-1) x d(-1) (G+4E). The GOS and G+4E diets were formulated to ...