نتایج جستجو برای: gp73
تعداد نتایج: 112 فیلتر نتایج به سال:
Because primary liver cancer is a growing concern showing poor prognosis due to its rapid infiltrating power and complicating liver cirrhosis; more attention were given to address the causal risk factors that could be preventable and/or treatable. 2 HCC is phenotypically and genetically heterogeneous tumor, reflecting in part the heterogeneity of etiologic factors involved in (i) the onset of H...
Golgi apparatus is the organelle mainly functioning as protein processing and secretion. GOLPH2 is a resident Golgi glycoprotein, usually called GP73. Recent data displayed that GOLPH2 is a superb hepatocellular carcinoma (HCC) marker candidate, and even its specificity is better than liver cancer marker AFP. Oncolytic adenoviruses are broadly used for targeting cancer therapy due to their sele...
Golgi phosphoprotein 2 (GOLPH2) is a resident Golgi type-II membrane protein upregulated in liver disease. Given that GOLPH2 traffics through endosomes and can be secreted into the circulation, it is a promising serum marker for liver diseases. The structure of GOLPH2 and the functions of its different protein domains are not known. In the current study, we investigated the structural determina...
BACKGROUND/AIMS TGF-β plays a key role in the progression of various tumors. The main objective of our study was to investigate whether TGF-β is able to regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) progression in a mouse model by inducing Treg cell polarization. METHODS HCC progression, TGF-β and Foxp3 expression levels, serum TGF-β, IL10 and GP73 levels as well...
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