PURPOSE GRIM-19 has been shown to be down-regulated in cervical cancers. This study investigated the expression of GRIM-19 in cervical intra-epithelial neoplasias and its association with high-risk human papillomavirus (HR-HPV) infection. METHODS The expression of GRIM-19 was assessed in cervical exfoliated cells and cervical intra-epithelial neoplasia tissues by immunohistochemistry, and the...

OBJECTIVE Human papillomavirus (HPV) testing is widely incorporated into cervical cancer screening strategies. Current screening requires pelvic examination for cervical sampling, which may compromise participation. The acceptance could be raised by introducing testing on vaginal swabs. We explored the interchangeability of vaginal swabs and cervical smears for HPV testing, by means of a prospe...

Gains of 3q26 chromosome region, where the human telomerase RNA gene (hTERC) is located, have been previously documented in cervical carcinomas and preneoplastic lesions. The aim of our study was to define the value of 3q26 gains related to persistence-progression in cervical specimens with cytologic diagnosis for low-grade squamous intraepithelial lesions, using liquid-based cytology (ThinPrep...

BACKGROUND p16 (INK4a) (p16) is a well-recognized surrogate molecular marker for human papilloma virus (HPV) related squamous dysplasia. Our hypothesis is that the invasive interventions and related morbidities could be avoided by objective stratification of positive cytologic interpretations by p16 immunostaining of cell block sections of cytology specimens. MATERIALS AND METHODS Nuclear imm...

CONTEXT Persistent infection with high risk human papillomavirus (HPV) has been linked to cervical carcinoma. Integration of viral DNA into host cell DNA is essential for this cancer development, promoting disruption of the HPV E2 gene, thus leading to unregulated increases in E6 and E7 proteins and inactivating the products of p53 and Rb tumor suppressor genes. OBJECTIVE To investigate HPV 1...

Objective : An attempt was made to compare the detection of cervical abnormalities between the use of a cotton swab and a Cervex brush in mass cancer screening. Study Design : Of 15,664 women who participated in a cervical cancer screening program in 2002, 8,366 women underwent Cervex brush sampling and 7,298 underwent cotton swab screening to compare the detectability of dysplasia and cancer i...

BACKGROUND Split-sample clinical trials for liquid-based Papanicolaou (Pap) smears demonstrated that the liquid-based Pap smear was a safe and effective replacement for the conventional Pap smear. However, clinical intended use of liquid-based technology employs direct-to-vial collection methods. The current study compared the cytologic detection rates of the liquid-based Pap smear with convent...

Background & Objective: This study aimed to examine the extent which postcoital bleeding (PCB) can be a predictive factor for cervical cancer. Materials Methods: In this observational we selected and evaluated 280 females with PCB referred Kowsar Hospital of Qazvin, Iran from 2017 2019. Results: Among 189 patients diagnosed as normal in their Pap smear results, one patient had cancer her b...

ABSTRACT
 Objective: The aim of our study is to compare the clinical data and colposcopy- directed biopsy (CDB) results atypical squamous cell undetermined significance (ASC-US) low-grade intraepithelial lesion (LSIL) cytology among high risk human papilloma virus (hrHPV) positive women.
 Materials Methods: A total 359 hrHPV-positive patients with ASC-US LSIL cytology, between 20-67 y...

OBJECTIVE Nucleolar organizer region (NOR) associated proteins are argyrophilic and visualized by silver stains. AgNOR pleomorphic dots increase in cancer and most researchers have done a common count of single dots. Pleomorphic dots are few and perhaps indicate a more severe prognosis. The present study was aimed at investigating the relative preponderance and diagnostic value of both pleomorp...