Abstract Polycaprolactone (PCL) is widely applied for the construction of small-diameter tissue-engineered vascular grafts (TEGs) due to its biomechanical properties, slow degradation, and good biocompatibility. In present study TEG based on a tubular scaffold seeded with smooth muscle aortic cells (SMCs) in rat abdominal aorta replacement model was tested. Polyester scaffolds were generated by...

In the past decade, thoracic endovascular aortic repair (TEVAR) has become the primary treatment option in descending aneurysm and dissection. The clinical outcome of this minimally invasive technique is strictly related to an appropriate patient/stent graft selection, hemodynamic interactions, and operator skills. In this context, a quantitative assessment of the biomechanical stress induced i...

Background/objective The purpose of this study was to elucidate the biomechanical differences between anterior cruciate ligament (ACL) grafts reconstructed by isometric and anatomic reconstruction techniques, based on their length changes. Methods One hundred and thirty-three knees with primary ACL reconstruction using the bone-patellar tendon-bone (BTB) graft were retrospectively identified....

Autologous bone-patellar tendon-bone autograft is a common choice for anterior cruciate ligament reconstruction and from both biologic and biomechanical perspectives is well-suited for this purpose. A centrally harvested, 10 mm wide patellar tendon graft has an estimated initial load-to-failure of 2977 N, and interference screw fixation of associated bone blocks provides initial pull-out streng...

BACKGROUND Knowledge of the impact of viable medial meniscus allograft and autograft transplantation on biochemical and mechanical properties of cartilage is needed to understand the development of joint osteoarthritis. The purpose of this study was to evaluate this relationship 6 months after viable medial meniscal autograft and allograft transplantation. METHODS Twenty rabbits were chosen f...

Blood flow in end-to-side autogenous or prosthetic graft anastomoses is of great interest to biomedical researchers because the biomechanical force profile engendered by blood flow disturbances at such geometric transitions is thought to play a significant role in vascular remodeling and graft failure. Thus, investigators have extensively studied anastomotic blood flow patterns in relationship ...

Despite the popularity of anterior cruciate ligament (ACL) reconstruction procedures, the ideal graft for reconstruction remains a matter of controversy. The ideal graft for ACL reconstruction should have histologic and biomechanical characteristics similar to those of the native ACL; should be quickly and fully incorporated within the bony tunnels; should maintain its viscoelastic properties f...

Stem cell-mediated gene therapy for fracture repair, utilizes genetically engineered mesenchymal stem cells (MSCs) for the induction of bone growth and is considered a promising approach in skeletal tissue regeneration. Previous studies have shown that murine nonunion fractures can be repaired by implanting MSCs over-expressing recombinant human bone morphogenetic protein-2 (rhBMP-2). Nanoinden...

Along with insights into the potential for graft success, knowledge of biomechanical properties of small diameter tissue-engineered blood vessel (TEBV) will enable designers to tailor the vessels' mechanical response to closer resemble that of native tissue. Composed of two layers that closely mimic the native media and adventitia, a tissue-engineered vascular adventitia (TEVA) is wrapped aroun...