The intestinal tract provides an important reservoir for antibiotic-resistant gram-negative bacilli, including Enterobacteriaceae species, Pseudomonas aeruginosa, and Acinetobacter baumannii. Selective pressure exerted by antibiotics plays a crucial role in the emergence and dissemination of these pathogens. Many classes of antibiotics may promote intestinal colonization by health care-associat...

background : gram-negative bacteria are the most cause of nosocomial infection especially in burned patients. carbapenem resistant strains can limit seriously the choice of antibiotic therapy. ampc can make resistance to carbapenem and detection of that can be useful for identification of carbapenem resistant. the aim of this study was identification of ampc in most prevalent cause of nosocomia...

Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical ...

A novel vector has been constructed for the constitutive luminescent tagging of gram-negative bacteria by site-specific integration into the 16S locus of the bacterial chromosome. A number of gram-negative pathogens were successfully tagged using this vector, and the system was validated during murine infections of living animals.

It has been shown that injection of lipopolysaccharides, derived from a variety of Gram-negative bacterial species, evokes in mice a rapidly developing rise in resistance to infection with Gram-negative pathogens. This is accompanied by an elevation in properdin titer, at times to levels 2 to 3 times the normal. The rate, magnitude, and duration of these responses are dependent on many factors,...

BACKGROUND Infection is still a frequent cause of morbidity and mortality in acute myelogenous leukemia (AML) patients receiving chemotherapy. Recently the main cause of infection has changed from gram-negative to gram-positive bacteria and the resistance to antibiotics has increased. This study aimed to access the effectiveness of antimicrobial prophylaxis (AP) with orally absorbable antibioti...

A randomized, double-blind, placebo-controlled trial was conducted in eight hematologic units to determine the efficacy and safety of oral enoxacin for infection prevention in adult patients with acute nonlymphocytic leukemia. One hundred nineteen patients undergoing remission induction or consolidation chemotherapy were enrolled; 62 of them received enoxacin (400 mg orally every 12 h). Patient...

Backgrounds: Neutropenia can be associated with life-threatening infections. Gram negative and staphylococcal infections are the most common pathogens. The spectrum of bacterial isolates has changed considerably over the past four decades. The objective of the present study was to evaluate the pattern of bacterial and fungal infections in neutropenic pediatric patients. Methods: A non-randomize...

        Freshwater crayfish (Astacus leptodactylus) is an important economic fisheries resource of Aras reservoir, Iran. The infection of freshwater crayfish by gram negative and gram positive bacteria are common in natural and cultural environments. These bacteria are considered as secondary disease agents or opportunities. This study was conducted to investigate infes...

backgrounds: neutropenia can be associated with life-threatening infections. gram negative and staphylococcal infections are the most common pathogens. the spectrum of bacterial isolates has changed considerably over the past four decades. the objective of the present study was to evaluate the pattern of bacterial and fungal infections in neutropenic pediatric patients.   methods: a non-randomi...