About 20 % of neonates develop sepsis and among them approximately 1% die due to sepsis-related causes. Bacterial pathogens are the commonest cause neonatal which is either early-onset (<72 hours age) or late-onset (>72 hours). Little known about epidemiology antimicrobial susceptibility pattern causing bacterial in Nepal. A prospective study was carried out suspected have admitted Tribhu...

OBJECTIVE The use of corticosteroids in patients with sepsis or septic shock has been controversial for many decades. Clinical studies have reported beneficial, as well as negative results. We conducted a meta-analysis to assess the clinical evidence and to evaluate treatment effects in specific subgroups of patients. DESIGN Meta-analysis. DATA SOURCES A comprehensive search of the literatu...

Background: Neonatal sepsis remains a leading cause of morbidity and mortality among neonates clinical manifestations are non-specific. Delayed identification inappropriate treatment remain as key factors causing high neonatal mortality. Increasing emergence multidrug-resistant organisms reduces antibiotic options. Hence there is need for institutional guidelines based on local microbial preval...

Bacterial infection and sepsis are associated with renal tubule dysfunction and dysregulation of systemic electrolyte balance but the underlying mechanisms are incompletely understood. Recently, we demonstrated that HCO(3)(-) absorption by the medullary thick ascending limb (MTAL) is inhibited by gram-negative bacterial LPS through activation of Toll-like receptor 4 (TLR4). Here, we examined wh...

background urinary tract infection (uti) is one of the most common bacterial diseasesworldwidethat can be presented asymptomatic or symptomatic, characterized by a wide range of symptoms from mild irritative voiding to bacteremia, sepsis, or even death. in latter decades, widespread utilization of antibiotics has resulted in increased incidence of antibiotic resistance among urinary tract patho...

BACKGROUND Sepsis and subsequent multiple-organ failure are the predominant causes of late mortality in trauma patients. Susceptibility and response to infection is, in part, heritable. Single-nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) and cluster of differentiation 14 (CD14) genes of innate immunity may play a key role. The aim of this study was to assess if SNPs in TLR/CD14 p...

background sepsis can be defined as the body’s response to an infection. sepsis in children remains a significant cause of morbidity and mortality worldwide. objectives this study focuses on the etiological factors, risk factors, and clinical characteristics of sepsis in neonate and pediatric patients. patients and methods a prospective study was conducted over a six-month period in the pediatr...

OBJECTIVE Bacterial sepsis continues to be a major cause of morbidity and mortality in newborns. Bacterial pathogens of neonatal septicemia may vary from one country to another and within a country from one hospital or region to another. Both gram-negative and gram-positive bacteria are responsible in neonatal sepsis. This study was undertaken to determine the prevalent bacterial agents of neon...

BACKGROUND Consistent data about sepsis in Mexico are lacking. The objective of this epidemiological study is to better define the incidence, characteristics and outcome of sepsis in Mexican intensive care units (ICUs). METHODS This is a multicenter, transverse study performed in both private and public ICUs. Demographic data, comorbid diseases and clinical and laboratory data were collected ...

Introduction Neonatal sepsis is a leading cause of neonatal mortality and morbidity in the world. The objective of the current study was to detect the common causative microorganisms of neonatal sepsis and their antimicrobial resistance patterns in a rural secondary hospital in Tamil Nadu, India. Materials and Methods Neonates (0-28 days) admitted to this newborn care unit from October 2013 t...